3-benzyl-3,4-dihydro-8-methoxy-1-methyl-1,4-ethano-1H-3-benzazepin-5(2H)-one

Base Information

• Chemical Name: 3-benzyl-3,4-dihydro-8-methoxy-1-methyl-1,4-ethano-1H-3-benzazepin-5(2H)-one
• CAS No.: 105166-48-1
• Molecular Formula: C₂₁H₂₃NO₂
• Molecular Weight: 321.419
• Mol file: 105166-48-1.mol

Synonyms:

Chemical Property of 3-benzyl-3,4-dihydro-8-methoxy-1-methyl-1,4-ethano-1H-3-benzazepin-5(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzyl-3,4-dihydro-8-methoxy-1-methyl-1,4-ethano-1H-3-benzazepin-5(2H)-one

There total 13 articles about 3-benzyl-3,4-dihydro-8-methoxy-1-methyl-1,4-ethano-1H-3-benzazepin-5(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-benzyl-2,3,4,5-tetrahydro-8-methoxy-1-methyl-1,4-ethano-1H-3-benzazepin-5-ol (105166-47-0) → 3-benzyl-3,4-dihydro-8-methoxy-1-methyl-1,4-ethano-1H-3-benzazepin-5(2H)-one (105166-48-1)

Guidance literature:

With chromium(VI) oxide; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

ETHYL 3-METHOXYPHENYLACETATE (35553-92-5) → 3-benzyl-3,4-dihydro-8-methoxy-1-methyl-1,4-ethano-1H-3-benzazepin-5(2H)-one (105166-48-1)

Guidance literature:

Multi-step reaction with 9 steps

1: 81 percent / sodium, iron(III) nitrate / liquid ammonia; diethyl ether / 2.5 h / -78 °C

2: 70 percent / 1.) n-butyl-lithium/di-isopropylamine; 2.) HMPA / tetrahydrofuran / 0.25 h / -72 °C

3: 60 percent / sodium hydroxide / aq. ethanol / 18 h / Heating

4: 76 percent / polyphosphoric acid / 24 h / 45 °C

5: 76 percent / sodium hydride / toluene / 3 h / 75 °C

6: 83 percent / phenyltrimethylammonium perbromide / tetrahydrofuran / 1 h / 0 °C

7: 76 percent / sodium hydride, 15-crown-5-ether / toluene / Ambient temperature

8: 46 percent / lithium aluminium hydride / tetrahydrofuran / 4 h / Heating

9: 0.4 g / chromium trioxide / CH₂Cl₂ / 0.5 h / 20 °C

With chromium(VI) oxide; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; PPA; 15-crown-5; sodium; phenyltrimethylammonium tribromide; sodium hydride; ferric nitrate; diisopropylamine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; ammonia; toluene;

Reference yield:

m-methoxyphenylacetic acid (1798-09-0) → 3-benzyl-3,4-dihydro-8-methoxy-1-methyl-1,4-ethano-1H-3-benzazepin-5(2H)-one (105166-48-1)

Guidance literature:

Multi-step reaction with 10 steps

1: 80 percent / conc. sulphuric acid / 2.5 h / Heating

2: 81 percent / sodium, iron(III) nitrate / liquid ammonia; diethyl ether / 2.5 h / -78 °C

3: 70 percent / 1.) n-butyl-lithium/di-isopropylamine; 2.) HMPA / tetrahydrofuran / 0.25 h / -72 °C

4: 60 percent / sodium hydroxide / aq. ethanol / 18 h / Heating

5: 76 percent / polyphosphoric acid / 24 h / 45 °C

6: 76 percent / sodium hydride / toluene / 3 h / 75 °C

7: 83 percent / phenyltrimethylammonium perbromide / tetrahydrofuran / 1 h / 0 °C

8: 76 percent / sodium hydride, 15-crown-5-ether / toluene / Ambient temperature

9: 46 percent / lithium aluminium hydride / tetrahydrofuran / 4 h / Heating

10: 0.4 g / chromium trioxide / CH₂Cl₂ / 0.5 h / 20 °C

With chromium(VI) oxide; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; PPA; 15-crown-5; sulfuric acid; sodium; phenyltrimethylammonium tribromide; sodium hydride; ferric nitrate; diisopropylamine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; ammonia; toluene;

upstream raw materials:

3-benzyl-2,3,4,5-tetrahydro-8-methoxy-1-methyl-1,4-ethano-1H-3-benzazepin-5-ol

ETHYL 3-METHOXYPHENYLACETATE

m-methoxyphenylacetic acid

2-(3-methoxyphenyl)propanoic acid ethyl ester