1-(2-chlorophenyl)-N,4-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide

Base Information

Chemical Name:1-(2-chlorophenyl)-N,4-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
CAS No.:1417409-40-5
Molecular Formula:C₁₈H₁₄ClN₅O
Molecular Weight:351.795
Hs Code.:

Synonyms:

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Chemical Property of 1-(2-chlorophenyl)-N,4-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide

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Technology Process of 1-(2-chlorophenyl)-N,4-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide

There total 9 articles about 1-(2-chlorophenyl)-N,4-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1417411-00-7
1-(2-chlorophenyl)-4-methyl[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxylic acid

: 74-89-5
methylamine

: 1417409-40-5
1-(2-chlorophenyl)-N,4-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide

Guidance literature:: With N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 2h;
DOI:10.1021/acs.jmedchem.8b00713

Reference yield:

: 1417411-50-7
ethyl 3-chloro-2-methylquinoxaline-6-carboxylate

: 1417409-40-5
1-(2-chlorophenyl)-N,4-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: butan-1-ol / 3 h / 160 °C / Sealed tube

2: lithium hydroxide / water; tetrahydrofuran / 2 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide / N,N-dimethyl-formamide / 2 h

With N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/acs.jmedchem.8b00713

Reference yield:

: 103039-33-4
4-((1-carboxyethyl)amino)-3-nitrobenzoic acid

: 1417409-40-5
1-(2-chlorophenyl)-N,4-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydrogencarbonate; hydrogen / water / 60 h / 3102.97 Torr

2: sodium hydroxide; dihydrogen peroxide / water / 16 h / 100 °C

3: sulfuric acid / 16 h / 80 °C

4: trichlorophosphate / N,N-dimethyl-aniline / 2 h / 20 - 120 °C

5: butan-1-ol / 3 h / 160 °C / Sealed tube

6: lithium hydroxide / water; tetrahydrofuran / 2 h / 20 °C

7: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide / N,N-dimethyl-formamide / 2 h

With N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; sulfuric acid; hydrogen; dihydrogen peroxide; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; water; N,N-dimethyl-aniline; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/acs.jmedchem.8b00713