C₄₁H₅₂N₂O₆S

Base Information

• Chemical Name: C₄₁H₅₂N₂O₆S
• CAS No.: 1422258-30-7
• Molecular Formula: C₄₁H₅₂N₂O₆S
• Molecular Weight: 700.94
• Mol file: 1422258-30-7.mol

Synonyms:

Chemical Property of C₄₁H₅₂N₂O₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₁H₅₂N₂O₆S

There total 6 articles about C₄₁H₅₂N₂O₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

C20H34N2O4S (1422258-29-4) + 4,4'-dimethoxytrityl chloride (40615-36-9) → C41H52N2O6S (1422258-30-7)

Guidance literature:

With methyl-phenyl-thioether; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1093/nar/gkt197

Reference yield:

Octanethiol (111-88-6) → C41H52N2O6S (1422258-30-7)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile

2: tetrabutyl ammonium fluoride / tetrahydrofuran

3: methyl-phenyl-thioether; N-ethyl-N,N-diisopropylamine / dichloromethane

With methyl-phenyl-thioether; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1093/nar/gkt197

Reference yield:

3',5'-Bis-O-(tert-butyldimethylsilyl)-4-O-<(2,4,6-triisopropylphenyl)sulfonyl>thymidine (114021-22-6) → C41H52N2O6S (1422258-30-7)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium bromide; potassium carbonate / water; 1,4-dioxane

2: acetonitrile

3: tetrabutyl ammonium fluoride / tetrahydrofuran

4: methyl-phenyl-thioether; N-ethyl-N,N-diisopropylamine / dichloromethane

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; methyl-phenyl-thioether; tetrabutyl ammonium fluoride; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium bromide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile; 1: |Suzuki-Miyaura Coupling;

DOI:10.1093/nar/gkt197

upstream raw materials:

Octanethiol

thymidine

C₂₀H₃₄N₂O₄S

4,4'-dimethoxytrityl chloride

Downstream raw materials:

C₅₀H₆₉N₄O₇PS