3-((4aR,6S,8aS)-6-Benzyloxy-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-6-methyl-2,4-bis-(2-trimethylsilanyl-ethoxymethoxy)-benzoic acid ethyl ester

Base Information Edit

Chemical Name:3-((4aR,6S,8aS)-6-Benzyloxy-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-6-methyl-2,4-bis-(2-trimethylsilanyl-ethoxymethoxy)-benzoic acid ethyl ester
CAS No.:299428-90-3
Molecular Formula:C₄₄H₇₀O₇Si₂
Molecular Weight:767.207
Hs Code.:
Mol file:299428-90-3.mol

3-((4aR,6S,8aS)-6-Benzyloxy-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-6-methyl-2,4-bis-(2-trimethylsilanyl-ethoxymethoxy)-benzoic acid ethyl ester

Synonyms:

Suppliers and Price of 3-((4aR,6S,8aS)-6-Benzyloxy-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-6-methyl-2,4-bis-(2-trimethylsilanyl-ethoxymethoxy)-benzoic acid ethyl ester

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-((4aR,6S,8aS)-6-Benzyloxy-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-6-methyl-2,4-bis-(2-trimethylsilanyl-ethoxymethoxy)-benzoic acid ethyl ester Edit

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-((4aR,6S,8aS)-6-Benzyloxy-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-6-methyl-2,4-bis-(2-trimethylsilanyl-ethoxymethoxy)-benzoic acid ethyl ester

There total 2 articles about 3-((4aR,6S,8aS)-6-Benzyloxy-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-6-methyl-2,4-bis-(2-trimethylsilanyl-ethoxymethoxy)-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115404-48-3
(3S,4aR,8aS)-3-Benzyloxy-8-bromomethyl-4,4,7,8a-tetramethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

: 261506-17-6
ethyl 3-iodo-6-methyl-2,4-bis[2-(trimethylsilyl)ethyloxymethoxy]benzoate

: 299428-90-3
3-((4aR,6S,8aS)-6-Benzyloxy-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-6-methyl-2,4-bis-(2-trimethylsilanyl-ethoxymethoxy)-benzoic acid ethyl ester

Guidance literature:: ethyl 3-iodo-6-methyl-2,4-bis[2-(trimethylsilyl)ethyloxymethoxy]benzoate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

In tetrahydrofuran; hexane; at -78 - -10 ℃;

(3S,4aR,8aS)-3-Benzyloxy-8-bromomethyl-4,4,7,8a-tetramethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene; In tetrahydrofuran; hexane; at -78 ℃; for 2h;
DOI:10.1271/bbb.64.1410

Reference yield:

: 115333-56-7
(4aR,6S,8aS)-(+)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-1-hydroxymethyl-2,5,5,8a-tetramethylnaphthalene

: 299428-90-3
3-((4aR,6S,8aS)-6-Benzyloxy-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-6-methyl-2,4-bis-(2-trimethylsilanyl-ethoxymethoxy)-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: PBr₃ / diethyl ether / -20 °C

2.1: BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: CuCN / hexane; tetrahydrofuran / -78 - -10 °C

2.3: tetrahydrofuran; hexane / 2 h / -78 °C

With n-butyllithium; phosphorus tribromide; In tetrahydrofuran; diethyl ether; hexane; 1.1: Substitution / 2.1: Metallation / 2.2: Metallation / 2.3: Substitution;
DOI:10.1271/bbb.64.1410