1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-[(2-pyrrolidin-1-yl-acetylamino)-methyl]-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide

Base Information

• Chemical Name: 1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-[(2-pyrrolidin-1-yl-acetylamino)-methyl]-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide
• CAS No.: 65699-31-2
• Molecular Formula: C₂₅H₂₆Cl₂N₆O₃
• Molecular Weight: 529.426
• Mol file: 65699-31-2.mol

Synonyms:

Chemical Property of 1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-[(2-pyrrolidin-1-yl-acetylamino)-methyl]-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-[(2-pyrrolidin-1-yl-acetylamino)-methyl]-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide

There total 9 articles about 1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-[(2-pyrrolidin-1-yl-acetylamino)-methyl]-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

pyrrolidine (123-75-1) + 2',5-dichloro-2-(3-dimethylcarbamoyl-5-chloroacetylaminomethyl-1H-1,2,4-triazol-1-yl)benzophenone (65699-27-6) → 1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-[(2-pyrrolidin-1-yl-acetylamino)-methyl]-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide (65699-31-2)

Guidance literature:

In methanol; chloroform; water; for 72h; Ambient temperature;

DOI:10.1002/jhet.5570190621

Reference yield:

8-chloro-6-(2-chloro-phenyl)-4H-benzo[f][1,2,4]triazolo[1,5-a][1,4]diazepine-2-carboxylic acid dimethylamide (50330-59-1) → 1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-[(2-pyrrolidin-1-yl-acetylamino)-methyl]-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide (65699-31-2)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. HBr / Heating

2: 90 percent / benzene; dimethylformamide / 3 h

3: 75 percent / CHCl₃; methanol; H₂O / 72 h / Ambient temperature

With hydrogen bromide; In methanol; chloroform; water; N,N-dimethyl-formamide; benzene;

DOI:10.1002/jhet.5570190621

Reference yield:

N,N-dimethyl 2-amino-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetamide (65698-99-9) → 1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-[(2-pyrrolidin-1-yl-acetylamino)-methyl]-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide (65699-31-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 47 percent / K₂CO₃ / tetrahydrofuran; dimethylformamide / Ambient temperature; overnight

2: 30percent HBr/acetic acid / 2 h / Ambient temperature

3: 90 percent / benzene; dimethylformamide / 3 h

4: 75 percent / CHCl₃; methanol; H₂O / 72 h / Ambient temperature

With hydrogen bromide; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide; benzene;

DOI:10.1002/jhet.5570190621

upstream raw materials:

pyrrolidine

2',5-dichloro-2-(3-dimethylcarbamoyl-5-chloroacetylaminomethyl-1H-1,2,4-triazol-1-yl)benzophenone

8-chloro-6-(2-chloro-phenyl)-4H-benzo[f][1,2,4]triazolo[1,5-a][1,4]diazepine-2-carboxylic acid dimethylamide

N,N-dimethyl 2-amino-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetamide