Technology Process of methyl 2,3,4-tri-O-benzyl-6-O-(2,4,6-tri-O-acetyl-3-O-benzyl-β-D-glucopyranosyl)-α-D-glucopyranoside
There total 3 articles about methyl 2,3,4-tri-O-benzyl-6-O-(2,4,6-tri-O-acetyl-3-O-benzyl-β-D-glucopyranosyl)-α-D-glucopyranoside which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: NaOAc / 4 h / 110 °C
2: 74 percent / 1.) crushed molecular sieves (4 Angstroem); 2.) trimethylsilyl trifluoromethanesulfonate / CH2Cl2 / 1.) r.t., 0.5 h; 2.) -20 deg C to r.t.
With
trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; sodium acetate;
In
dichloromethane;
DOI:10.1016/0008-6215(89)84070-4
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaH (60percent dispersion in oil); 2.) 60percent aq. acetic acid; 3.) 0.1M H2SO4 / 1.) DMF, 90 deg C, 2 h; 2.) 90 deg C, 2 h; 3.) 90 deg C, 2 h
2: NaOAc / 4 h / 110 °C
3: 74 percent / 1.) crushed molecular sieves (4 Angstroem); 2.) trimethylsilyl trifluoromethanesulfonate / CH2Cl2 / 1.) r.t., 0.5 h; 2.) -20 deg C to r.t.
With
trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; sulfuric acid; sodium acetate; sodium hydride; acetic acid;
In
dichloromethane;
DOI:10.1016/0008-6215(89)84070-4
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaH (60percent dispersion in oil); 2.) 60percent aq. acetic acid; 3.) 0.1M H2SO4 / 1.) DMF, 90 deg C, 2 h; 2.) 90 deg C, 2 h; 3.) 90 deg C, 2 h
2: NaOAc / 4 h / 110 °C
3: 74 percent / 1.) crushed molecular sieves (4 Angstroem); 2.) trimethylsilyl trifluoromethanesulfonate / CH2Cl2 / 1.) r.t., 0.5 h; 2.) -20 deg C to r.t.
With
trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; sulfuric acid; sodium acetate; sodium hydride; acetic acid;
In
dichloromethane;
DOI:10.1016/0008-6215(89)84070-4
