3-(Hydroxy-diphenyl-methyl)-pyridine-2-carboxylic acid diisopropylamide

Base Information

• Chemical Name: 3-(Hydroxy-diphenyl-methyl)-pyridine-2-carboxylic acid diisopropylamide
• CAS No.: 77923-98-9
• Molecular Formula: C₂₅H₂₈N₂O₂
• Molecular Weight: 388.51
• Mol file: 77923-98-9.mol

Synonyms:

Chemical Property of 3-(Hydroxy-diphenyl-methyl)-pyridine-2-carboxylic acid diisopropylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(Hydroxy-diphenyl-methyl)-pyridine-2-carboxylic acid diisopropylamide

There total 3 articles about 3-(Hydroxy-diphenyl-methyl)-pyridine-2-carboxylic acid diisopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzophenone (119-61-9) + N,N-diisopropyl pyridine-2-carboxamide (77923-97-8) → 3-(Hydroxy-diphenyl-methyl)-pyridine-2-carboxylic acid diisopropylamide (77923-98-9)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; ether, -78 deg C, 2 h;

DOI:10.1016/0040-4039(80)88108-1

Reference yield:

2-picolinoyl chloride hydrochloride (39901-94-5) → 3-(Hydroxy-diphenyl-methyl)-pyridine-2-carboxylic acid diisopropylamide (77923-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NEt₃

2: 1.) (i-Pr)2NLi / 1.) Et₂O, C₆H₆, -78 deg C, 1 h, 2.) -78 deg C, 2 h; 25 deg C, 1.5 h

With triethylamine; lithium diisopropyl amide;

Reference yield:

diisopropylamine (108-18-9) → 3-(Hydroxy-diphenyl-methyl)-pyridine-2-carboxylic acid diisopropylamide (77923-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NEt₃

2: 1.) (i-Pr)2NLi / 1.) Et₂O, C₆H₆, -78 deg C, 1 h, 2.) -78 deg C, 2 h; 25 deg C, 1.5 h

With triethylamine; lithium diisopropyl amide;

upstream raw materials:

benzophenone

N,N-diisopropyl pyridine-2-carboxamide

2-picolinoyl chloride hydrochloride

diisopropylamine

Downstream raw materials:

diphenyl-5,5 (5H)furo<3,4-b>pyridinone-7