5-(4-phenoxyphenyl)-5-{4-[2-(2-{2-[2-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2,4,6-trione

Base Information

Chemical Name:5-(4-phenoxyphenyl)-5-{4-[2-(2-{2-[2-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2,4,6-trione
CAS No.:1351556-77-8
Molecular Formula:C₃₉H₅₄N₄O₁₂
Molecular Weight:770.877
Hs Code.:

5-(4-phenoxyphenyl)-5-{4-[2-(2-{2-[2-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2,4,6-trione

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Chemical Property of 5-(4-phenoxyphenyl)-5-{4-[2-(2-{2-[2-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2,4,6-trione

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Technology Process of 5-(4-phenoxyphenyl)-5-{4-[2-(2-{2-[2-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2,4,6-trione

There total 9 articles about 5-(4-phenoxyphenyl)-5-{4-[2-(2-{2-[2-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2,4,6-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-bromo-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione

: 1351556-74-5
4-[2-(2-{2-[2-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl]piperazin-1-ium trifluoroacetate

: 1351556-77-8
5-(4-phenoxyphenyl)-5-{4-[2-(2-{2-[2-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2,4,6-trione

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 5 - 20 ℃;
DOI:10.1021/jm201142w

Reference yield:

: 1351556-80-3
1,1,1-triphenyl-2,5,8,11,14,17,20,23,26-nonaoxanonacos-28-yne

: 1351556-77-8
5-(4-phenoxyphenyl)-5-{4-[2-(2-{2-[2-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2,4,6-trione

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / methanol / Reflux

1.2: 20 °C

2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

3.1: triethylamine / acetonitrile / Reflux

4.1: dichloromethane / 0 - 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 5 - 20 °C

With potassium carbonate; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm201142w

Reference yield:

: 112-60-7
Tetraethylene glycol

: 1351556-77-8
5-(4-phenoxyphenyl)-5-{4-[2-(2-{2-[2-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2,4,6-trione

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / tert-butyl alcohol / Reflux

1.2: Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C

2.2: 20 °C

3.1: toluene-4-sulfonic acid / methanol / Reflux

3.2: 20 °C

4.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

5.1: triethylamine / acetonitrile / Reflux

6.1: dichloromethane / 0 - 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 5 - 20 °C

With potassium tert-butylate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil; tert-butyl alcohol;
DOI:10.1021/jm201142w