5-[4-(2-{2-[2-(2-{2-[2-(2-{2-[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl-methoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione

Base Information

• Chemical Name: 5-[4-(2-{2-[2-(2-{2-[2-(2-{2-[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl-methoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione
• CAS No.: 1351556-88-1
• Molecular Formula: C₄₁H₅₈FN₇O₁₂
• Molecular Weight: 859.95
• Mol file: 1351556-88-1.mol

Synonyms:

Chemical Property of 5-[4-(2-{2-[2-(2-{2-[2-(2-{2-[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl-methoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[4-(2-{2-[2-(2-{2-[2-(2-{2-[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl-methoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione

There total 10 articles about 5-[4-(2-{2-[2-(2-{2-[2-(2-{2-[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl-methoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

1-azido-2-fluoroethane (894792-94-0) + 5-(4-phenoxyphenyl)-5-{4-[2-(2-{2-[2-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2,4,6-trione (1351556-77-8) → 5-[4-(2-{2-[2-(2-{2-[2-(2-{2-[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl-methoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione (1351556-88-1)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1021/jm201142w

Reference yield:

1,1,1-triphenyl-2,5,8,11,14,17,20,23,26-nonaoxanonacos-28-yne (1351556-80-3) → 5-[4-(2-{2-[2-(2-{2-[2-(2-{2-[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl-methoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione (1351556-88-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / methanol / Reflux

1.2: 20 °C

2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

3.1: triethylamine / acetonitrile / Reflux

4.1: dichloromethane / 0 - 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 5 - 20 °C

6.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; N,N-dimethyl-formamide / 24 h / 20 °C

With copper(ll) sulfate pentahydrate; potassium carbonate; toluene-4-sulfonic acid; sodium L-ascorbate; triethylamine; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm201142w

Reference yield:

Tetraethylene glycol (112-60-7) → 5-[4-(2-{2-[2-(2-{2-[2-(2-{2-[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl-methoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione (1351556-88-1)

Guidance literature:

Multi-step reaction with 8 steps

1.1: potassium tert-butylate / tert-butyl alcohol / Reflux

1.2: Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C

2.2: 20 °C

3.1: toluene-4-sulfonic acid / methanol / Reflux

3.2: 20 °C

4.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

5.1: triethylamine / acetonitrile / Reflux

6.1: dichloromethane / 0 - 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 5 - 20 °C

8.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; N,N-dimethyl-formamide / 24 h / 20 °C

With copper(ll) sulfate pentahydrate; potassium tert-butylate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; sodium L-ascorbate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil; tert-butyl alcohol;

DOI:10.1021/jm201142w

upstream raw materials:

1-azido-2-fluoroethane

5-(4-phenoxyphenyl)-5-{4-[2-(2-{2-[2-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2,4,6-trione

2-(2-{2-[2-(2-{2-[2-(2-trityloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethanol

4-[2-(2-{2-[2-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl]piperazin-1-ium trifluoroacetate