Technology Process of 6,7-dimethoxy-1-(3-methoxy-benzoyl)-isoquinoline-4-carboxylic acid methoxy-amide trifluoroacetate salt
There total 9 articles about 6,7-dimethoxy-1-(3-methoxy-benzoyl)-isoquinoline-4-carboxylic acid methoxy-amide trifluoroacetate salt which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
water;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: ethanol; sodium / toluene / 2 h / 80 - 85 °C
1.2: 2 h / 80 °C
2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 2844.39 Torr
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane
4.1: phosphorus pentachloride / dichloromethane / 20 °C
5.1: sulfur / 0.42 h / 165 °C
6.1: selenium(IV) oxide / acetic acid / 0.33 h / Heating / reflux
7.1: sodium hydroxide; water / methanol / 1 h / Heating / reflux
8.1: triethylamine; isobutyl chloroformate / DMF (N,N-dimethyl-formamide) / 0.5 h / 0 °C
8.2: 2 h / 20 °C
9.1: water / 0.5 h
With
hydrogenchloride; sodium hydroxide; selenium(IV) oxide; ethanol; phosphorus pentachloride; water; hydrogen; sodium; benzotriazol-1-ol; sulfur; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isobutyl chloroformate;
palladium 10% on activated carbon;
In
methanol; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane; water; acetic acid; toluene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 2844.39 Torr
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane
3.1: phosphorus pentachloride / dichloromethane / 20 °C
4.1: sulfur / 0.42 h / 165 °C
5.1: selenium(IV) oxide / acetic acid / 0.33 h / Heating / reflux
6.1: sodium hydroxide; water / methanol / 1 h / Heating / reflux
7.1: triethylamine; isobutyl chloroformate / DMF (N,N-dimethyl-formamide) / 0.5 h / 0 °C
7.2: 2 h / 20 °C
8.1: water / 0.5 h
With
hydrogenchloride; sodium hydroxide; selenium(IV) oxide; phosphorus pentachloride; water; hydrogen; benzotriazol-1-ol; sulfur; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isobutyl chloroformate;
palladium 10% on activated carbon;
In
methanol; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane; water; acetic acid;
