3-ethyl-5-methyl-(-)-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:3-ethyl-5-methyl-(-)-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:191285-84-4
Molecular Formula:C₂₇H₃₆Cl₂N₂O₈
Molecular Weight:587.497
Hs Code.:

3-ethyl-5-methyl-(-)-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Synonyms:

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Chemical Property of 3-ethyl-5-methyl-(-)-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

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Technology Process of 3-ethyl-5-methyl-(-)-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 9 articles about 3-ethyl-5-methyl-(-)-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 191285-82-2
(-)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine-5-carboxylic acid

: 74-88-4
methyl iodide

: 191285-84-4
3-ethyl-5-methyl-(-)-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: With N-benzyl-trimethylammonium hydroxide; In ethanol; N,N-dimethyl-formamide; at 40 ℃; for 0.166667h;
DOI:10.1016/S0968-0896(97)00024-2

Reference yield:

: 5197-62-6
2-[2-(chloroethoxy)ethoxy]ethanol

: 191285-84-4
3-ethyl-5-methyl-(-)-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: 89 percent / DMF / 17 h / Heating

2: 90 percent / Jones reagent / acetone / 1 h

3: 1.) carbonyldiimidazole, 2.) pyridine / 1.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, RT, 48 h

4: 4 h / Heating

5: 41 percent / ammonium formate / ethanol / 72 h / 40 °C

6: 71 percent / 40percent aq. methylamine / 5 h / Ambient temperature

7: 85 percent / aq. K₂CO₃ / tetrahydrofuran / 2 h / 0 °C

8: tetrabutylammonium fluoride / tetrahydrofuran / 24 h / Ambient temperature

9: trimethylbenzylammonium hydroxide / ethanol; dimethylformamide / 0.17 h / 40 °C

With pyridine; jones reagent; tetrabutyl ammonium fluoride; ammonium formate; N-benzyl-trimethylammonium hydroxide; potassium carbonate; N,N-dimethyl-formamide; 1,1'-carbonyldiimidazole; methylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0968-0896(97)00024-2

Reference yield:

: 75001-09-1
2-(2-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)ethoxy)acetic acid

: 191285-84-4
3-ethyl-5-methyl-(-)-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) carbonyldiimidazole, 2.) pyridine / 1.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, RT, 48 h

2: 4 h / Heating

3: 41 percent / ammonium formate / ethanol / 72 h / 40 °C

4: 71 percent / 40percent aq. methylamine / 5 h / Ambient temperature

5: 85 percent / aq. K₂CO₃ / tetrahydrofuran / 2 h / 0 °C

6: tetrabutylammonium fluoride / tetrahydrofuran / 24 h / Ambient temperature

7: trimethylbenzylammonium hydroxide / ethanol; dimethylformamide / 0.17 h / 40 °C

With pyridine; tetrabutyl ammonium fluoride; ammonium formate; N-benzyl-trimethylammonium hydroxide; potassium carbonate; 1,1'-carbonyldiimidazole; methylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00024-2