Benzenebutanoic acid, 4-(methylthio)-

Base Information

• Chemical Name: Benzenebutanoic acid, 4-(methylthio)-
• CAS No.: 116174-33-5
• Molecular Formula: C11H14O2S
• Molecular Weight: 210.297
• Mol file: 116174-33-5.mol

Synonyms:

Chemical Property of Benzenebutanoic acid, 4-(methylthio)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenebutanoic acid, 4-(methylthio)-

There total 8 articles about Benzenebutanoic acid, 4-(methylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-(4-methylsulfanyl-phenyl)-4-oxo-butyric acid (7028-67-3) → 4-(4-methylsulfanyl-phenyl)butyric acid (116174-33-5)

Guidance literature:

With triethylsilane; trifluoroacetic acid; at 0 ℃; for 17h;

DOI:10.1016/j.ejmech.2011.02.010

Reference yield:

4-(4-methylthiophenyl)-3-oxobutanoic acid → 4-(4-methylsulfanyl-phenyl)butyric acid (116174-33-5)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; In water; diethylene glycol;

Reference yield:

p-(methylthio)cinnamic acid (102016-58-0) → 4-(4-methylsulfanyl-phenyl)butyric acid (116174-33-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 100 mg / H₂ / Pd/C / ethyl acetate; ethanol / 168 h / 20 °C

2.1: 4.25 g / aq. H₂SO₄ / CH₂Cl₂ / Heating

3.1: 2.72 g / LiAlH₄ / diethyl ether

4.1: 1.18 g / PBr₃ / CCl₄ / 20 °C

5.1: I₂; Mg / diethyl ether / 20 °C

5.2: 160 mg / diethyl ether

With lithium aluminium tetrahydride; sulfuric acid; hydrogen; iodine; phosphorus tribromide; magnesium; palladium on activated charcoal; In tetrachloromethane; diethyl ether; ethanol; dichloromethane; ethyl acetate;

DOI:10.1002/chem.200400516

upstream raw materials:

4-(4-methylsulfanyl-phenyl)-4-oxo-butyric acid

(4-(3-bromopropyl)phenyl)(methyl)sulfane

carbon dioxide

methyl 3-[4-(methylthio)phenyl]propanoate

Downstream raw materials:

4-(4-(methylthio)phenyl)butan-1-ol