2-chloro-11-phenyl-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline

Base Information

Chemical Name:2-chloro-11-phenyl-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline
CAS No.:116690-73-4
Molecular Formula:C20H18ClN
Molecular Weight:307.823
Hs Code.:
DSSTox Substance ID:DTXSID30368948
Nikkaji Number:J1.982.028I
Wikidata:Q82155859
ChEMBL ID:CHEMBL3115419

Synonyms:2-chloro-11-phenyl-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline;116690-73-4;6H-Cyclohepta[b]quinoline, 2-chloro-7,8,9,10-tetrahydro-11-phenyl-;CHEMBL3115419;DTXSID30368948;AB00980979-01

Suppliers and Price of 2-chloro-11-phenyl-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-chloro-11-phenyl-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline

Chemical Property:

XLogP3:6.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:307.1127773
Heavy Atom Count:22
Complexity:365

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC2=C(C3=C(C=CC(=C3)Cl)N=C2CC1)C4=CC=CC=C4

Technology Process of 2-chloro-11-phenyl-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline

There total 6 articles about 2-chloro-11-phenyl-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 719-59-5
5-chloro-2-aminobenzophenone

: 502-42-1
cycloheptanone

: 116690-73-4
2-chloro-11-phenyl-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline

Guidance literature:: With tin(ll) chloride; at 20 ℃; for 0.75h;
DOI:10.1246/cl.2005.314

Reference yield: 64.0%

: (8-azidooct-1-yn-1-yl)benzene

: 144930-52-9
(4-chlorophenyl)(phenyl)iodonium triflate

: 116690-73-4
2-chloro-11-phenyl-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline

Guidance literature:: With copper(I) oxide; In 1,2-dichloro-ethane; at 60 ℃; for 24h; Sealed tube; Inert atmosphere;
DOI:10.1055/s-0034-1379248

Reference yield:

: 536-74-3
phenylacetylene

: 116690-73-4
2-chloro-11-phenyl-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C / Inert atmosphere

1.2: 2 h / -78 - 20 °C / Inert atmosphere

2.1: sodium azide / dimethyl sulfoxide / 36 h / 20 °C

3.1: copper(I) oxide / 1,2-dichloro-ethane / 24 h / 60 °C / Sealed tube; Inert atmosphere

With copper(I) oxide; n-butyllithium; sodium azide; In tetrahydrofuran; hexane; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1055/s-0034-1379248