1-Methanesulfonyl-4-<4-<-1,3-dioxolan-4-yl>methylenoxy>phenyl>piperazine

Base Information

• Chemical Name: 1-Methanesulfonyl-4-<4-<-1,3-dioxolan-4-yl>methylenoxy>phenyl>piperazine
• CAS No.: 67915-53-1
• Molecular Formula: C₂₅H₂₈Cl₂N₄O₅S
• Molecular Weight: 567.493
• Mol file: 67915-53-1.mol

Synonyms:

Chemical Property of 1-Methanesulfonyl-4-<4-<-1,3-dioxolan-4-yl>methylenoxy>phenyl>piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Methanesulfonyl-4-<4-<-1,3-dioxolan-4-yl>methylenoxy>phenyl>piperazine

There total 10 articles about 1-Methanesulfonyl-4-<4-<-1,3-dioxolan-4-yl>methylenoxy>phenyl>piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-<4-<-1,3-dioxolan-4-yl>methylenoxy>phenyl>piperazine (67914-61-8) + methanesulfonyl chloride (124-63-0) → 1-Methanesulfonyl-4-<4-<-1,3-dioxolan-4-yl>methylenoxy>phenyl>piperazine (67915-53-1,85058-98-6,133345-16-1)

Guidance literature:

In pyridine; for 2h;

DOI:10.1002/jhet.5570270739

Reference yield:

1-(4-hydroxy-phenyl)-piperazine dihydrobromide (38869-37-3) → 1-Methanesulfonyl-4-<4-<-1,3-dioxolan-4-yl>methylenoxy>phenyl>piperazine (67915-53-1,85058-98-6,133345-16-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / pyridine / 0.5 h

2: 1N aq. NaOH / 12 h / Heating

3: 1) NaH (60percent in mineral oil) / 1) DMSO, 1h, 2) DMSO, RT, overnight

With sodium hydroxide; sodium hydride; In pyridine;

DOI:10.1002/jhet.5570270739

Reference yield:

1-(4-hydroxy-phenyl)-piperazine dihydrobromide (38869-37-3) → 1-Methanesulfonyl-4-<4-<-1,3-dioxolan-4-yl>methylenoxy>phenyl>piperazine (67915-53-1,85058-98-6,133345-16-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / pyridine / 0.5 h

2: 1N aq. NaOH / 12 h / Heating

3: 1) NaH (60percent in mineral oil) / 1) DMSO, 1 h, 2) DMSO, 12 h

With sodium hydroxide; sodium hydride; In pyridine;

DOI:10.1002/jhet.5570270739

upstream raw materials:

trans-<2-(2,4-Dichlorophenyl)-2-<1H-imidazol-1-yl>methyl-(1,3-dioxolan-4-yl)>methyl methanesulfonate

1-(4-Hydroxyphenyl)-4-(methanesulfonyl)piperazine

1-(4-hydroxy-phenyl)-piperazine dihydrobromide

methanesulfonic acid 4-(4-methanesulfonylpiperazin-1-yl)phenyl ester