(αR)-Acetyloxybenzenebutanoic Acid

Base Information

• Chemical Name: (αR)-Acetyloxybenzenebutanoic Acid
• CAS No.: 117017-04-6
• Molecular Formula: C12H14O4
• Molecular Weight: 222.241
• Mol file: 117017-04-6.mol

Synonyms:(αR)-Acetyloxybenzenebutanoic Acid;(AlphaR)-Acetyloxybenzenebutanoic Acid;

Chemical Property of (αR)-Acetyloxybenzenebutanoic Acid

Chemical Property:

• PSA: 63.60000
• LogP: 1.63550
• Solubility.: Chloroform, Ethyl Acetate, Methanol

Purity/Quality:

(αR)-AcetyloxybenzenebutanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (αR)-Acetyloxybenzenebutanoic Acid is a reactant used in the preparation of Benazepril (B119750).

Technology Process of (αR)-Acetyloxybenzenebutanoic Acid

There total 7 articles about (αR)-Acetyloxybenzenebutanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

2-acetoxy-4-phenylbutanoic acid (883723-47-5) → (S)-2-hydroxy-4-phenylbutanoic acid (115016-95-0,111611-91-7) + (R)-2-acetoxy-4-phenylbutanoic acid (117017-04-6)

Guidance literature:

With phosphate buffer; Novozyme 435 Candida antarctica lipase B; In acetone; at 30 ℃; for 24h; pH=7.5;

DOI:10.1016/j.tet.2006.01.007

Reference yield: 45.0%

2-hydroxy-4-phenylbutanoic acid (4263-93-8,111611-91-7) → (R)-2-hydroxy4-phenylbutanoic acid (29678-81-7,111611-91-7) + (S)-2-acetoxy-4-phenylbutanoic acid (123736-87-8) + (R)-2-acetoxy-4-phenylbutanoic acid (117017-04-6)

Guidance literature:

With vinyl acetate; In various solvent(s); at 25 ℃; for 30h; Yields of byproduct given; lipase PS;

DOI:10.1016/0957-4166(95)00051-P

Reference yield: 45.0%

vinyl acetate (108-05-4,9003-20-7) + 2-hydroxy-4-phenylbutanoic acid (4263-93-8,111611-91-7) → (R)-2-hydroxy4-phenylbutanoic acid (29678-81-7,111611-91-7) + (S)-2-acetoxy-4-phenylbutanoic acid (123736-87-8) + (R)-2-acetoxy-4-phenylbutanoic acid (117017-04-6)

Guidance literature:

In various solvent(s); at 25 ℃; for 30h; Yield given. Title compound not separated from byproducts; lipase PS;

DOI:10.1016/0957-4166(95)00051-P

upstream raw materials:

vinyl acetate

2-hydroxy-4-phenylbutanoic acid

2-acetoxy-4-phenylbutanoic acid

(R)-2-acetoxy-4-oxo-4-phenylbutyric acid

Downstream raw materials:

ethyl (R)-2-hydroxy-4-phenylbutyrate

(S)-2-hydroxy-4-phenylbutanoic acid

(S)-2-acetoxy-4-phenylbutanoic acid

(R)-2-hydroxy4-phenylbutanoic acid

Refernces

• 1、 -. "Process for producing optically active 2-hydroxy-4-arylbutyric acid or its ester". . . Retrieved 2008/06/13.
• 2、 -. "Pyridazodiazepine derivatives". . . Retrieved 2008/06/13.