Benzeneacetic acid, a-hydroxy-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Benzeneacetic acid, a-hydroxy-, 1,1-dimethylethyl ester
• CAS No.: 117356-18-0
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• Mol file: 117356-18-0.mol

Synonyms:

Chemical Property of Benzeneacetic acid, a-hydroxy-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, a-hydroxy-, 1,1-dimethylethyl ester

There total 56 articles about Benzeneacetic acid, a-hydroxy-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,2-dihydroxy-1-phenyl-ethanone (1075-06-5) + tert-butyl alcohol (75-65-0) → tert-butyl (S)-2-hydroxy-2-phenylacetate (4768-43-8,89015-28-1,117356-18-0,107740-74-9)

Guidance literature:

With iron(III) chloride; C₄₃H₆₄N₄O₄; oxygen; In dichloromethane; at 30 ℃; for 51h; Reagent/catalyst; Time; Solvent; enantioselective reaction; Molecular sieve;

DOI:10.1039/c5cc04213e

Reference yield: 90.0%

tert-butyl glyoxylate (7633-32-1) + phenylboronic acid (98-80-6) → tert-butyl (S)-2-hydroxy-2-phenylacetate (4768-43-8,89015-28-1,117356-18-0,107740-74-9)

Guidance literature:

With (R)-Me-BIPAM; potassium fluoride; tris(triphenylphosphine)ruthenium(II) chloride; water; In toluene; at 80 ℃; for 16h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c2cc17339e

Reference yield: 88.0%

tert-butyl phenylglyoxylate (7332-98-1) → β-hydroxy β-phenyl acetate de t-butyle (117356-18-0)

Guidance literature:

With water; sodium acetate; bis-diphenylphosphinomethane; cobalt(II) iodide; zinc; In acetonitrile; at 80 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1002/adsc.201900636

upstream raw materials:

t-butyl phenylacetate

3,3-dimethyldioxirane

phenylglyoxal hydrate

tert-butyl alcohol

Downstream raw materials:

tert-butyl benzoylacetate

tert-butyl phenylglyoxylate

(R)-α-hydroxyphenylacetic acid tert-butyl ester

t-butyl N-(Phth)-(D)-aminoxymandelate