Technology Process of 1,3,5(10)-estratriene-2,3,7α,17β-tetraol 2,3,17-tribenzyl ether
There total 11 articles about 1,3,5(10)-estratriene-2,3,7α,17β-tetraol 2,3,17-tribenzyl ether which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1.) pyridinium chloride / 1.) 1 h, 200 deg C; 2.) pyridine, 1 h, r.t.
2: 56 percent / CrO3 / acetic acid; H2O / 1 h / 0 °C
3: 54 percent / NaBH4 / tetrahydrofuran; ethanol / 1.5 h
4: 93 percent / K2CO3 / dimethylformamide / 16 h
5: 89 percent / KOH / methanol / 2 h
6: 57 percent / 50percent NaH / dimethylformamide
7: CH2Cl2 / 0.17 h / 0 °C
8: 1 N NaOH / tetrahydrofuran; methanol / 1 h
9: 1.) thionyl chloride; 2.) LiAlH4 / 1.) THF, 0 deg C, 1 h; 2.) THF, reflux, 1 h
With
chromium(VI) oxide; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; thionyl chloride; pyridine hydrochloride; sodium hydride; potassium carbonate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/recl.19831021003
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 56 percent / CrO3 / acetic acid; H2O / 1 h / 0 °C
2: 54 percent / NaBH4 / tetrahydrofuran; ethanol / 1.5 h
3: 93 percent / K2CO3 / dimethylformamide / 16 h
4: 89 percent / KOH / methanol / 2 h
5: 57 percent / 50percent NaH / dimethylformamide
6: CH2Cl2 / 0.17 h / 0 °C
7: 1 N NaOH / tetrahydrofuran; methanol / 1 h
8: 1.) thionyl chloride; 2.) LiAlH4 / 1.) THF, 0 deg C, 1 h; 2.) THF, reflux, 1 h
With
chromium(VI) oxide; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; thionyl chloride; sodium hydride; potassium carbonate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/recl.19831021003
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 57 percent / 50percent NaH / dimethylformamide
2: CH2Cl2 / 0.17 h / 0 °C
3: 1 N NaOH / tetrahydrofuran; methanol / 1 h
4: 1.) thionyl chloride; 2.) LiAlH4 / 1.) THF, 0 deg C, 1 h; 2.) THF, reflux, 1 h
With
sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; sodium hydride;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/recl.19831021003
