2-methyl-4-[4-(4-nitro-phenyl)-thiazol-2-yl]-oxazole

Base Information

• Chemical Name: 2-methyl-4-[4-(4-nitro-phenyl)-thiazol-2-yl]-oxazole
• CAS No.: 96461-28-8
• Molecular Formula: C₁₃H₉N₃O₃S
• Molecular Weight: 287.299
• Mol file: 96461-28-8.mol

Synonyms:

Chemical Property of 2-methyl-4-[4-(4-nitro-phenyl)-thiazol-2-yl]-oxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-4-[4-(4-nitro-phenyl)-thiazol-2-yl]-oxazole

There total 5 articles about 2-methyl-4-[4-(4-nitro-phenyl)-thiazol-2-yl]-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-4-carbethoxy-1,3-oxazole (10200-43-8) → 2-methyl-4-[4-(4-nitro-phenyl)-thiazol-2-yl]-oxazole (96461-28-8)

Guidance literature:

Multi-step reaction with 5 steps

1: aq. NH₃

2: P₂O₅

3: H₂S, Et₃N / ethanol

4: piperidine / ethanol

5: HNO₃

With piperidine; ammonium hydroxide; hydrogen sulfide; nitric acid; phosphorus pentoxide; triethylamine; In ethanol;

DOI:10.1002/hlca.19600430610

Reference yield:

2-Methyloxazole-4-carboxamide (100959-91-9) → 2-methyl-4-[4-(4-nitro-phenyl)-thiazol-2-yl]-oxazole (96461-28-8)

Guidance literature:

Multi-step reaction with 4 steps

1: P₂O₅

2: H₂S, Et₃N / ethanol

3: piperidine / ethanol

4: HNO₃

With piperidine; hydrogen sulfide; nitric acid; phosphorus pentoxide; triethylamine; In ethanol;

DOI:10.1002/hlca.19600430610

Reference yield:

2-methyl-4-oxazolecarbonitrile (89282-09-7) → 2-methyl-4-[4-(4-nitro-phenyl)-thiazol-2-yl]-oxazole (96461-28-8)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂S, Et₃N / ethanol

2: piperidine / ethanol

3: HNO₃

With piperidine; hydrogen sulfide; nitric acid; triethylamine; In ethanol;

DOI:10.1002/hlca.19600430610

upstream raw materials:

2-methyl-4-(4-phenyl-thiazol-2-yl)-oxazole

2-methyl-4-carbethoxy-1,3-oxazole

2-methyl-4-oxazolecarbonitrile

2-Methyloxazole-4-carboxamide