Technology Process of ((2R,4R)-4-Benzenesulfonylmethyl-6,6-dimethoxy-2-methyl-hexyloxy)-tert-butyl-diphenyl-silane
There total 12 articles about ((2R,4R)-4-Benzenesulfonylmethyl-6,6-dimethoxy-2-methyl-hexyloxy)-tert-butyl-diphenyl-silane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: NEt3, DMAP / CH2Cl2 / 3 h / Ambient temperature
2: KCN, NaI / dimethylsulfoxide / 12 h / 50 °C
3: DIBAH / hexane; CH2Cl2 / 0.75 h / -78 °C
4: Amberlyst 15 / methanol; CH2Cl2 / 4 h / Ambient temperature
With
dmap; potassium cyanide; Amberlyst 15; diisobutylaluminium hydride; triethylamine; sodium iodide;
In
methanol; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(97)00945-3
- Guidance literature:
-
Multi-step reaction with 10 steps
1: NaH / toluene; dimethylformamide / 5 h / 80 °C
2: LAH / tetrahydrofuran / 4 h / 0 °C
3: 93 percent / pig pancrease lipase / tetrahydrofuran / 336 h / Ambient temperature
4: DMAP / pyridine / 24 h / 0 °C
5: NaCN / dimethylsulfoxide / 4 h / 90 °C
6: K2CO3 / methanol / 3 h / 0 °C
7: I2, PPh3, imidazole / acetonitrile; diethyl ether / 3 h / 0 °C
8: dimethylformamide / 24 h / Ambient temperature
9: DIBAH / hexane; CH2Cl2 / 0.75 h / -78 °C
10: Amberlyst 15 / methanol; CH2Cl2 / 4 h / Ambient temperature
With
1H-imidazole; dmap; lithium aluminium tetrahydride; Amberlyst 15; pig pancrease lipase; sodium cyanide; iodine; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine;
In
tetrahydrofuran; pyridine; methanol; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0040-4039(97)00945-3
- Guidance literature:
-
Multi-step reaction with 4 steps
1: NEt3, DMAP / CH2Cl2 / 3 h / Ambient temperature
2: KCN, NaI / dimethylsulfoxide / 12 h / 50 °C
3: DIBAH / hexane; CH2Cl2 / 0.75 h / -78 °C
4: Amberlyst 15 / methanol; CH2Cl2 / 4 h / Ambient temperature
With
dmap; potassium cyanide; Amberlyst 15; diisobutylaluminium hydride; triethylamine; sodium iodide;
In
methanol; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(97)00945-3
