cyclo<-D-Lys-Arg-Glu-Val-Tyr->*2HOAc

Base Information

• Chemical Name: cyclo<-D-Lys-Arg-Glu-Val-Tyr->*2HOAc
• CAS No.: 100164-89-4
• Molecular Formula: 2C₂H₄O₂*C₃₁H₄₉N₉O₈
• Molecular Weight: 795.891
• Mol file: 100164-89-4.mol

Synonyms:

Chemical Property of cyclo<-D-Lys-Arg-Glu-Val-Tyr->*2HOAc

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclo<-D-Lys-Arg-Glu-Val-Tyr->*2HOAc

There total 22 articles about cyclo<-D-Lys-Arg-Glu-Val-Tyr->*2HOAc which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid (55878-47-2) → cyclo<-D-Lys-Arg-Glu-Val-D-Tyr->*2HOAc (100164-89-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 95 percent / NMM, PPA / CH₂Cl₂ / 1.)-15 deg C to room temp., 2.)2d room temp.

2: 95 percent / 1N NaOH / methanol / 4 h / Ambient temperature

3: 56 percent / NMM, PPA / CH₂Cl₂ / 1.)-15 deg C to room temp., 2.) 2d room temp.

4: 1.)TFA, 2.)NMM,DMAP,EDCI / 1.) DMF/CH₂Cl₂, 5d, -2 to 5 degC_., 2.) 1d, room temp.

5: hydrogen / 10percent Pd/C / methanol / 6 h / Ambient temperature

With 4-methyl-morpholine; dmap; sodium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1002/jlac.198619860507

Reference yield:

(R)-6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid (55878-47-2) → cyclo<-D-Lys-Arg-Glu-Val-Tyr->*2HOAc (100164-89-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 95 percent / NMM, PPA / CH₂Cl₂ / 1.)-15 deg C to room temp., 2.)2d room temp.

2: 95 percent / 1N NaOH / methanol / 4 h / Ambient temperature

3: 56 percent / NMM, PPA / CH₂Cl₂ / 1.)-15 deg C to room temp., 2.) 2d room temp.

4: 1.)TFA, 2.)NMM,DMAP,EDCI / 1.) DMF/CH₂Cl₂, 5d, -2 to 5 degC_., 2.) 1d, room temp.

5: hydrogen / 10percent Pd/C / methanol / 6 h / Ambient temperature

With 4-methyl-morpholine; dmap; sodium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1002/jlac.198619860507

Reference yield:

Nω-nitro-L-arginine methyl ester hydrochloride (51298-62-5) → cyclo<-D-Lys-Arg-Glu-Val-D-Tyr->*2HOAc (100164-89-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 95 percent / NMM, PPA / CH₂Cl₂ / 1.)-15 deg C to room temp., 2.)2d room temp.

2: 95 percent / 1N NaOH / methanol / 4 h / Ambient temperature

3: 56 percent / NMM, PPA / CH₂Cl₂ / 1.)-15 deg C to room temp., 2.) 2d room temp.

4: 1.)TFA, 2.)NMM,DMAP,EDCI / 1.) DMF/CH₂Cl₂, 5d, -2 to 5 degC_., 2.) 1d, room temp.

5: hydrogen / 10percent Pd/C / methanol / 6 h / Ambient temperature

With 4-methyl-morpholine; dmap; sodium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1002/jlac.198619860507

upstream raw materials:

acetic acid

cyclo<-D-Lys(Z)-Arg(NO2)-Glu(OBzl)-Val-Tyr->

(R)-6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid

Ddz-Glu(OBzl)-OH

Refernces