4-({3-[acetyl(hydroxy)amino]propyl}amino)-2-[2-({3-[acetyl(hydroxy)amino]propyl}amino)-2-oxoethyl]-2-hydroxy-4-oxobutanoic acid

Base Information

• Chemical Name: 4-({3-[acetyl(hydroxy)amino]propyl}amino)-2-[2-({3-[acetyl(hydroxy)amino]propyl}amino)-2-oxoethyl]-2-hydroxy-4-oxobutanoic acid
• CAS No.: 12040-70-9
• Molecular Formula: C₁₆H₂₈N₄O₉
• Molecular Weight: 420.42
• Mol file: 12040-70-9.mol

Synonyms:

Chemical Property of 4-({3-[acetyl(hydroxy)amino]propyl}amino)-2-[2-({3-[acetyl(hydroxy)amino]propyl}amino)-2-oxoethyl]-2-hydroxy-4-oxobutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-({3-[acetyl(hydroxy)amino]propyl}amino)-2-[2-({3-[acetyl(hydroxy)amino]propyl}amino)-2-oxoethyl]-2-hydroxy-4-oxobutanoic acid

There total 20 articles about 4-({3-[acetyl(hydroxy)amino]propyl}amino)-2-[2-({3-[acetyl(hydroxy)amino]propyl}amino)-2-oxoethyl]-2-hydroxy-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-tert-butyl-1,3-((3-N-hydroxy-3-N-acetyl)propyl)diamide citrate (114340-60-2) → schizokinen (35418-52-1,12040-70-9)

Guidance literature:

With trifluoroacetic acid; for 0.5h;

Reference yield: 65.0%

2-acetoxy-4-((3-(N-(benzoyloxy)acetamido)propyl)amino)-2-(2-((3-(N-(benzoyloxy)acetamido) propyl)amino)-2-oxoethyl)-4-oxobutanoic acid → schizokinen (35418-52-1,12040-70-9) + N-hydroxy-N-(2-(2-(3-hydroxy-1-(2-(N-hydroxyacetamido)ethyl)-2,5-dioxopyrrolidin-3-yl)acetamido)ethyl)acetamide

Guidance literature:

2-acetoxy-4-((3-(N-(benzoyloxy)acetamido)propyl)amino)-2-(2-((3-(N-(benzoyloxy)acetamido) propyl)amino)-2-oxoethyl)-4-oxobutanoic acid; With sodium hydroxide; at 20 ℃; for 0.5h;

With hydrogenchloride; pH=7;

DOI:10.1039/c9dt02731a

Reference yield:

Sodium; 3-[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-2-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-2-hydroxy-propionate (83948-78-1) → schizokinen (35418-52-1,12040-70-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; water; for 3h; under 760 Torr; Yield given; Ambient temperature;

DOI:10.1021/jo00149a005

upstream raw materials:

N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid benzyl ester

Sodium; 3-[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-2-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-2-hydroxy-propionate

2-tert-butyl-1,3-((3-N-hydroxy-3-N-acetyl)propyl)diamide citrate

2-tert-butyl-1,3-di-N-(hydroxyl) succinimidyl citrate