N-Boc-2,N-dideuterioaniline

Base Information

• Chemical Name: N-Boc-2,N-dideuterioaniline
• CAS No.: 1259100-79-2
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 195.23
• Mol file: 1259100-79-2.mol

Synonyms:

Chemical Property of N-Boc-2,N-dideuterioaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Boc-2,N-dideuterioaniline

There total 3 articles about N-Boc-2,N-dideuterioaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-N-(tert-butoxycarbonyl)aniline (78839-75-5) → N-Boc-2,N-dideuterioaniline (1259100-79-2)

Guidance literature:

2-bromo-N-(tert-butoxycarbonyl)aniline; With methyllithium; tert.-butyl lithium; In tetrahydrofuran; diethyl ether; pentane; at -40 ℃;

With water-d2; In tetrahydrofuran; diethyl ether; pentane; at -40 - 20 ℃;

DOI:10.1002/asia.201000613

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → N-Boc-2,N-dideuterioaniline (1259100-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 24 h / Reflux; Inert atmosphere

2.1: methyllithium; tert.-butyl lithium / tetrahydrofuran; diethyl ether; pentane / -40 °C

2.2: -40 - 20 °C

With methyllithium; tert.-butyl lithium; In tetrahydrofuran; diethyl ether; pentane;

DOI:10.1002/asia.201000613

Reference yield:

2-bromoaniline (615-36-1) → N-Boc-2,N-dideuterioaniline (1259100-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 24 h / Reflux; Inert atmosphere

2.1: methyllithium; tert.-butyl lithium / tetrahydrofuran; diethyl ether; pentane / -40 °C

2.2: -40 - 20 °C

With methyllithium; tert.-butyl lithium; In tetrahydrofuran; diethyl ether; pentane;

DOI:10.1002/asia.201000613

upstream raw materials:

di-tert-butyl dicarbonate

2-bromo-N-(tert-butoxycarbonyl)aniline

2-bromoaniline

Downstream raw materials:

2-acetamidocinnamic acid methyl ester

[2'-²H]acetanilide