5-bromo-N-(2-(diethylamino)ethyl)picolinamide

Base Information

• Chemical Name: 5-bromo-N-(2-(diethylamino)ethyl)picolinamide
• CAS No.: 1285446-04-9
• Molecular Formula: C₁₂H₁₈BrN₃O
• Molecular Weight: 300.198
• Mol file: 1285446-04-9.mol

Synonyms:

Chemical Property of 5-bromo-N-(2-(diethylamino)ethyl)picolinamide

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-N-(2-(diethylamino)ethyl)picolinamide

There total 1 articles about 5-bromo-N-(2-(diethylamino)ethyl)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-bromoisonicotinic acid (30766-11-1) + N,N-diethylethylenediamine (100-36-7) → 5-bromo-N-(2-(diethylamino)ethyl)picolinamide (1285446-04-9)

Guidance literature:

5-bromoisonicotinic acid; With O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 60 ℃; for 3h;

N,N-diethylethylenediamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1021/jm301740k

Reference yield:

5-bromo-N-(2-(diethylamino)ethyl)picolinamide (1285446-04-9) → toluene-4-sulfonic acid 2-(2-[2-{6-(2-diethylamino-ethylcarbamoyl)pyridin-3-yloxy}ethoxy]ethoxy)ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / paraffin oil; N,N-dimethyl-formamide / 20 h / 100 °C

2: pyridine / 4 h / 0 - 20 °C

With pyridine; sodium hydride; In N,N-dimethyl-formamide; paraffin oil;

DOI:10.1021/acs.molpharmaceut.7b00607

upstream raw materials:

5-bromoisonicotinic acid

N,N-diethylethylenediamine