ethyl N-(diphenylmethylidene)-3-(2-methoxy-3-pyridinyl)alaninate

Base Information

• Chemical Name: ethyl N-(diphenylmethylidene)-3-(2-methoxy-3-pyridinyl)alaninate
• CAS No.: 1361225-05-9
• Molecular Formula: C₂₄H₂₄N₂O₃
• Molecular Weight: 388.466
• Mol file: 1361225-05-9.mol

Synonyms:

Chemical Property of ethyl N-(diphenylmethylidene)-3-(2-methoxy-3-pyridinyl)alaninate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl N-(diphenylmethylidene)-3-(2-methoxy-3-pyridinyl)alaninate

There total 2 articles about ethyl N-(diphenylmethylidene)-3-(2-methoxy-3-pyridinyl)alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-methoxy-pyridin-3-yl)-methanol (112197-16-7) → ethyl N-(diphenylmethylidene)-3-(2-methoxy-3-pyridinyl)alaninate (1361225-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 20 °C

2: sodium hydroxide / tetrahydrofuran / 24 h / 20 °C

With carbon tetrabromide; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

2-methoxynicotinic acid (16498-81-0) → ethyl N-(diphenylmethylidene)-3-(2-methoxy-3-pyridinyl)alaninate (1361225-05-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 16 h / 70 °C

1.2: 0.33 h / 0 °C

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran / 24 h / 20 °C

With carbon tetrabromide; dimethylsulfide borane complex; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

ethyl N-(diphenylmethylidene)-3-(2-methoxy-3-pyridinyl)alaninate (1361225-05-9) → 1,1,1,3,3,3-hexafluoro-2-(4-(2-((2-methoxy-3-pyridinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol (1361225-04-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / methanol / 36 h / 70 °C

5.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 70 °C

5.2: 0.33 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h / 0 °C

7.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos / toluene / 18 h / 100 °C

With hydrogenchloride; dimethylsulfide borane complex; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

(2-methoxy-pyridin-3-yl)-methanol

2-methoxynicotinic acid

Downstream raw materials:

1,1,1,3,3,3-hexafluoro-2-(4-(2-((2-methoxy-3-pyridinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

2-((2-methoxy-3-pyridinyl)methyl)piperazine