1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-(4-hydroxymethyl-piperidin-1-yl)-ethanone

Base Information

Chemical Name:1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-(4-hydroxymethyl-piperidin-1-yl)-ethanone
CAS No.:1402048-32-1
Molecular Formula:C₄₂H₆₆N₂O₄S₂
Molecular Weight:727.129
Hs Code.:

1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-(4-hydroxymethyl-piperidin-1-yl)-ethanone

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Chemical Property of 1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-(4-hydroxymethyl-piperidin-1-yl)-ethanone

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Technology Process of 1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-(4-hydroxymethyl-piperidin-1-yl)-ethanone

There total 4 articles about 1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-(4-hydroxymethyl-piperidin-1-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 950-59-4
4-hydroxy-3,5-di-tert-butylthiophenol

: 1402048-32-1
1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-(4-hydroxymethyl-piperidin-1-yl)-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / methanol / 20 h / 45 °C

2.1: potassium tert-butylate / tetrahydrofuran / 5 h / Inert atmosphere; Reflux

3.1: isopropyl alcohol; potassium hydroxide / 18 h / Inert atmosphere; Reflux

3.2: 20 °C / pH ~ 6

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h

5.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

With hydrogenchloride; potassium tert-butylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; potassium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 1402048-32-1
1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-(4-hydroxymethyl-piperidin-1-yl)-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / methanol / 20 h / 45 °C

2.1: potassium tert-butylate / tetrahydrofuran / 5 h / Inert atmosphere; Reflux

3.1: isopropyl alcohol; potassium hydroxide / 18 h / Inert atmosphere; Reflux

3.2: 20 °C / pH ~ 6

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h

5.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

With hydrogenchloride; potassium tert-butylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; potassium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1402048-09-2
4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carboxylic acid ethyl ester

: 1402048-32-1
1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-(4-hydroxymethyl-piperidin-1-yl)-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropyl alcohol; potassium hydroxide / 18 h / Inert atmosphere; Reflux

1.2: 20 °C / pH ~ 6

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h

3.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; potassium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;