(2R)-3-methyl-2-butylamine

Base Information

• Chemical Name: (2R)-3-methyl-2-butylamine
• CAS No.: 110509-11-0
• Molecular Formula: C₅H₁₃N
• Molecular Weight: 87.1649
• Mol file: 110509-11-0.mol

Synonyms:

Chemical Property of (2R)-3-methyl-2-butylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-3-methyl-2-butylamine

There total 19 articles about (2R)-3-methyl-2-butylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.6%

3-methyl-butan-2-one (563-80-4) + 4-Phenyl-2-butanone (2550-26-7) → (2R)-3-methyl-2-butylamine (598-74-3,22526-46-1,34701-33-2,110509-11-0) + (R)-1-methyl-3-phenylpropylamine (937-52-0,22148-77-2,1199266-89-1)

Guidance literature:

With Candida boidinii formate dehydrogenase; pyridoxal 5'-phosphate; Aspergillus terreus ω-trans aminase; Lysinibacillus fusiformis leucine dehydrogenase; ammonium formate; nicotinamide adenine dinucleotide; In aq. buffer; at 30 ℃; for 24h; pH=8.8; Catalytic behavior; Green chemistry; Enzymatic reaction;

DOI:10.1021/acs.joc.9b02445

Reference yield:

(R)-1,2-dimethylpropylidene(1-phenylethyl)amine (31502-94-0) → (2R)-3-methyl-2-butylamine (598-74-3,22526-46-1,34701-33-2,110509-11-0)

Guidance literature:

With hydrogen; palladium hydroxide - carbon; In ethanol; under 7500.6 Torr; Ambient temperature;

Reference yield:

3-methyl-butan-2-one (563-80-4) → (2S)-3-methylbutan-2-amine (22526-46-1) + (2R)-3-methyl-2-butylamine (598-74-3,22526-46-1,34701-33-2,110509-11-0)

Guidance literature:

With ammonium iodide; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); 1,1'-Bis[(S)-4,5-dihydro-3H-binaphtho[2,1-c:1',2'-e]phosphepino]ferrocene; hydrogen; In methanol; toluene; at 80 ℃; for 36h; under 22502.3 Torr; Overall yield = 56 percent; enantioselective reaction; Autoclave;

DOI:10.1002/ejoc.202000750

upstream raw materials:

2-amino-3-methylbutane

(R)-1,2-dimethylpropylidene(1-phenylethyl)amine

(2R)-3-methyl-N-((R)-1-phenylethyl)butan-2-amine

Benzoic acid [1,2-dimethyl-prop-(E)-ylidene]-hydrazide

Downstream raw materials:

(R)-N-1-(i-propyl)ethyltosylamide

(R)-N-((R)-1,2-Dimethyl-propyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide