C₄₈H₄₂F₃N₃O₁₉

Base Information

• Chemical Name: C₄₈H₄₂F₃N₃O₁₉
• CAS No.: 169317-73-1
• Molecular Formula: C₄₈H₄₂F₃N₃O₁₉
• Molecular Weight: 1021.87
• Mol file: 169317-73-1.mol

Synonyms:

Chemical Property of C₄₈H₄₂F₃N₃O₁₉

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₈H₄₂F₃N₃O₁₉

There total 10 articles about C₄₈H₄₂F₃N₃O₁₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(7S,9S)-idarubicinone (60660-75-5) + p-Nitrobenzoyl 3-O-p-nitrobenzoyl-4-O-(3-N-trifluoroacetyl-4-O-p-nitrobenzoyl-α-L-daunosaminyl)-2-deoxy-L-fucoside (180182-58-5) → C48H42F3N3O19 (169317-73-1)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In diethyl ether; dichloromethane; at -20 ℃; for 1h;

DOI:10.1039/P19960001327

Reference yield:

2,3,6-trideoxy-1,4-di-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxopyranose (52583-22-9) → C48H42F3N3O19 (169317-73-1)

Guidance literature:

Multi-step reaction with 5 steps

1: TMSOTf / CH₂Cl₂ / 12 h / Ambient temperature

2: 4 Angstroem molecular sieves, iodonium dicollidine perchlorate / 1,2-dichloro-ethane; diethyl ether / 2 h / 5 - 10 °C

3: Ce(NH₄)2(NO₃)6 / acetonitrile; H₂O / Ambient temperature

4: pyridine / CH₂Cl₂ / 2 h / 0 °C

5: CF₃SO₃SiMe₃ / CH₂Cl₂; diethyl ether / 1 h / -20 °C

With pyridine; ammonium cerium(IV) nitrate; trimethylsilyl trifluoromethanesulfonate; iodonium di(2,4,6-trimethylpyridine) perchlorate; 4 A molecular sieve; In diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile;

DOI:10.1039/P19960001327

Reference yield:

4-nitro-benzoyl chloride (122-04-3) → C48H42F3N3O19 (169317-73-1)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / CH₂Cl₂ / 1 h / -15 °C

2: 4 Angstroem molecular sieves, iodonium dicollidine perchlorate / 1,2-dichloro-ethane; diethyl ether / 2 h / 5 - 10 °C

3: Ce(NH₄)2(NO₃)6 / acetonitrile; H₂O / Ambient temperature

4: pyridine / CH₂Cl₂ / 2 h / 0 °C

5: CF₃SO₃SiMe₃ / CH₂Cl₂; diethyl ether / 1 h / -20 °C

With pyridine; ammonium cerium(IV) nitrate; trimethylsilyl trifluoromethanesulfonate; iodonium di(2,4,6-trimethylpyridine) perchlorate; 4 A molecular sieve; In diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile;

DOI:10.1039/P19960001327

upstream raw materials:

(7S,9S)-idarubicinone

p-Nitrobenzoyl 3-O-p-nitrobenzoyl-4-O-(3-N-trifluoroacetyl-4-O-p-nitrobenzoyl-α-L-daunosaminyl)-2-deoxy-L-fucoside

2,3,6-trideoxy-1,4-di-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxopyranose

4-nitro-benzoyl chloride