N-(2-methylphenyl)propanamide

Base Information

• Chemical Name: N-(2-methylphenyl)propanamide
• CAS No.: 19343-15-8
• Molecular Formula: C10H13 N O
• Molecular Weight: 163.219
• Mol file: 19343-15-8.mol

Synonyms:o-Propionotoluidide(8CI); N-(2-Methylphenyl)propanamide; N-(2-Methylphenyl)propionamide;N-Propionyl-o-toluidine; N-o-Tolylpropionamide; NSC 204322;o-Methylpropionanilide

Chemical Property of N-(2-methylphenyl)propanamide

Chemical Property:

• Vapor Pressure: 0.00126mmHg at 25°C
• Boiling Point: 298.5°Cat760mmHg
• Flash Point: 177.2°C
• Density: 1.051g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-methylphenyl)propanamide

There total 8 articles about N-(2-methylphenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

propionic acid (802294-64-0,79-09-4) + o-toluidine (95-53-4) → N-o-tolylpropionamide (19343-15-8)

Guidance literature:

With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 5h;

DOI:10.1039/c9ob00699k

Reference yield: 80.0%

2-methylchlorobenzene (95-49-8) + Propionamid (79-05-0) → N-o-tolylpropionamide (19343-15-8)

Guidance literature:

With potassium carbonate; In glycerol; at 80 ℃; for 24h; Green chemistry;

DOI:10.1002/aoc.5723

Reference yield: 32.0%

2-tolyl isocyanate (614-68-6) + ethylzinc iodide (999-75-7) → N-o-tolylpropionamide (19343-15-8)

Guidance literature:

2-tolyl isocyanate; With [Rh(OH)(cod)]2; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere;

ethylzinc iodide; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00729

upstream raw materials:

propionic acid

o-toluidine

diethyl ether

Ethyl propionate

Downstream raw materials:

4-phenyl-1-o-tolylquinolin-2(1H)-one

ortho-methylfentanyl

(1-Phenethyl-piperidin-4-yl)-o-tolyl-amine

methylammonium carbonate

Refernces

• 1、 Bagheri, Sepideh,Pazoki, Farzane,Esfandiary, Naghmeh,Fadaei, Mohammad Mahdi,Heydari, Akbar. "Synthesis and characterization of Pd(II)–vitamin B6 complex supported on magnetic nanoparticle as an efficient and recyclable catalyst system for C–N cross coupling of amides in deep eutectic solvents". . . Retrieved 2020/06/04.
• 2、 Rajan. "Carboxyl activation of 2-mercapto-4,6-dimethylpyrimidine through n-acyl-4,6-dimethylpyrimidine-2-thione: A chemical and spectrophotometric investigation". . p. 287 - 291. Retrieved 2015/01/30.