Thymidine, 5'-deoxy-5'-[[(4-methoxyphenyl)diphenylmethyl]amino]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Base Information

• Chemical Name: Thymidine, 5'-deoxy-5'-[[(4-methoxyphenyl)diphenylmethyl]amino]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
• CAS No.: 118849-12-0
• Molecular Formula: C₃₉H₄₈N₅O₆P
• Molecular Weight: 713.814
• Mol file: 118849-12-0.mol

Synonyms:

Chemical Property of Thymidine, 5'-deoxy-5'-[[(4-methoxyphenyl)diphenylmethyl]amino]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thymidine, 5'-deoxy-5'-[[(4-methoxyphenyl)diphenylmethyl]amino]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

There total 10 articles about Thymidine, 5'-deoxy-5'-[[(4-methoxyphenyl)diphenylmethyl]amino]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + 5'-N-(4-methoxytrityl)-5'-amino-5'-deoxy-thymidine (118849-15-3) → 5'-N-(4-methoxytrityl)-5'-amino-5'-deoxy-thymidine-3'-(2-cyanoethyl-N,N-diisopropylphosphoramidite) (118849-12-0,120021-09-2,120021-10-5)

Guidance literature:

With bis(diisopropylammonium) tetrazolide; In dichloromethane; for 1h;

DOI:10.1002/hlca.19880710618

Reference yield: 87.0%

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + 5'-N-(4-methoxytrityl)-5'-amino-5'-deoxy-thymidine (118849-15-3) → 5'-N-(4-methoxytrityl)-5'-amino-5'-deoxy-thymidine-3'-(2-cyanoethyl-N,N-diisopropylphosphoramidite) (118849-12-0,120021-09-2,120021-10-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h;

Reference yield:

5'-amino-5'-deoxythymidine (25152-20-9) → 5'-N-(4-methoxytrityl)-5'-amino-5'-deoxy-thymidine-3'-(2-cyanoethyl-N,N-diisopropylphosphoramidite) (118849-12-0,120021-09-2,120021-10-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; 4-(dimethylamino)pyridine; pyridine

2: 61 percent / bis(diisopropylammonium)tetazolide / CH₂Cl₂

With pyridine; dmap; bis(diisopropylammonium)tetazolide; triethylamine; In dichloromethane;

DOI:10.1081/CAR-200059973

upstream raw materials:

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

5'-N-(4-methoxytrityl)-5'-amino-5'-deoxy-thymidine

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

5'-amino-5'-deoxythymidine

Downstream raw materials:

C₄₉H₆₁N₆O₁₁PSi