(5S,6S,7R,9Z,11R)-11-{2-[bis(4-methoxyphenyl)(phenyl)methoxy]ethyl}-5-{2-[(3,4-dimethoxybenzyl)oxy]ethyl}-2,2,3,3,6,13,13,14,14-nonamethyl-4,12-dioxa-3,13-disilapentadec-9-en-7-ol

Base Information

• Chemical Name: (5S,6S,7R,9Z,11R)-11-{2-[bis(4-methoxyphenyl)(phenyl)methoxy]ethyl}-5-{2-[(3,4-dimethoxybenzyl)oxy]ethyl}-2,2,3,3,6,13,13,14,14-nonamethyl-4,12-dioxa-3,13-disilapentadec-9-en-7-ol
• CAS No.: 1428671-98-0
• Molecular Formula: C₅₄H₈₀O₉Si₂
• Molecular Weight: 929.395

Synonyms:

Chemical Property of (5S,6S,7R,9Z,11R)-11-{2-[bis(4-methoxyphenyl)(phenyl)methoxy]ethyl}-5-{2-[(3,4-dimethoxybenzyl)oxy]ethyl}-2,2,3,3,6,13,13,14,14-nonamethyl-4,12-dioxa-3,13-disilapentadec-9-en-7-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5S,6S,7R,9Z,11R)-11-{2-[bis(4-methoxyphenyl)(phenyl)methoxy]ethyl}-5-{2-[(3,4-dimethoxybenzyl)oxy]ethyl}-2,2,3,3,6,13,13,14,14-nonamethyl-4,12-dioxa-3,13-disilapentadec-9-en-7-ol

There total 1 articles about (5S,6S,7R,9Z,11R)-11-{2-[bis(4-methoxyphenyl)(phenyl)methoxy]ethyl}-5-{2-[(3,4-dimethoxybenzyl)oxy]ethyl}-2,2,3,3,6,13,13,14,14-nonamethyl-4,12-dioxa-3,13-disilapentadec-9-en-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H36O5Si + {[(1R,2S)-1-{2-[bis(4-methoxyphenyl)(phenyl)methoxy]ethyl}-2-(4,4,5,5-tetraphenyl-1,3,2-dioxaborolan-2-yl)but-3-en-1-yl]oxy}(tert-butyl)dimethylsilan (1428671-97-9) → (5S,6S,7R,9Z,11R)-11-{2-[bis(4-methoxyphenyl)(phenyl)methoxy]ethyl}-5-{2-[(3,4-dimethoxybenzyl)oxy]ethyl}-2,2,3,3,6,13,13,14,14-nonamethyl-4,12-dioxa-3,13-disilapentadec-9-en-7-ol (1428671-98-0) + (5S,6S,7R,9E,11R)-11-{2-[bis(4-methoxyphenyl)(phenyl)methoxy]ethyl}-5-{2-[(3,4-dimethoxybenzyl)oxy]ethyl}-2,2,3,3,6,13,13,14,14-nonamethyl-4,12-dioxa-3,13-disilapentadec-9-en-7-ol

Guidance literature:

C₂₁H₃₆O₅Si; {[(1R,2S)-1-{2-[bis(4-methoxyphenyl)(phenyl)methoxy]ethyl}-2-(4,4,5,5-tetraphenyl-1,3,2-dioxaborolan-2-yl)but-3-en-1-yl]oxy}(tert-butyl)dimethylsilan; In dichloromethane; at -78 - 23 ℃; for 72.5h;

With ethanolamine; for 18h; Overall yield = 79 %; Overall yield = 2.79 g;

DOI:10.1021/ja401918r

Reference yield: 100.0%

(5S,6S,7R,9Z,11R)-11-{2-[bis(4-methoxyphenyl)(phenyl)methoxy]ethyl}-5-{2-[(3,4-dimethoxybenzyl)oxy]ethyl}-2,2,3,3,6,13,13,14,14-nonamethyl-4,12-dioxa-3,13-disilapentadec-9-en-7-ol (1428671-98-0) + 1,1,3,3-tetramethyldisilazane (15933-59-2) → C56H86O9Si3 (1428671-99-1)

Guidance literature:

at 20 ℃;

DOI:10.1021/ja401918r

Reference yield:

(5S,6S,7R,9Z,11R)-11-{2-[bis(4-methoxyphenyl)(phenyl)methoxy]ethyl}-5-{2-[(3,4-dimethoxybenzyl)oxy]ethyl}-2,2,3,3,6,13,13,14,14-nonamethyl-4,12-dioxa-3,13-disilapentadec-9-en-7-ol (1428671-98-0) → 3,9-bis-O-[tert-butyl(dimethyl)silyl]-2,4,6,8,10-pentadeoxy-1-O-(3,4-dimethoxybenzyl)-4-methyl-5,7-O-(oxomethylene)-D-glycero-D-gluco-undecitol (1428672-03-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 20 °C

2: toluene / 3 h / 0 °C

3: dihydrogen peroxide; potassium hydrogencarbonate / methanol; tetrahydrofuran

4: toluene / 2 h / 110 °C

5: acetic acid / dichloromethane / 2 h / 20 °C

With dihydrogen peroxide; potassium hydrogencarbonate; acetic acid; In tetrahydrofuran; methanol; dichloromethane; toluene;

DOI:10.1021/ja401918r

upstream raw materials:

{[(1R,2S)-1-{2-[bis(4-methoxyphenyl)(phenyl)methoxy]ethyl}-2-(4,4,5,5-tetraphenyl-1,3,2-dioxaborolan-2-yl)but-3-en-1-yl]oxy}(tert-butyl)dimethylsilan

Downstream raw materials:

C₅₆H₈₆O₉Si₃

3,9-bis-O-[tert-butyl(dimethyl)silyl]-2,4,6,8,10-pentadeoxy-1-O-(3,4-dimethoxybenzyl)-4-methyl-5,7-O-(oxomethylene)-D-glycero-D-gluco-undecitol

C₃₄H₆₀O₉Si₂

11-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3,9-bis-O-[tert-butyl(dimethyl)silyl]-2,4,6,8,10-pentadeoxy-1-O-(3,4-dimethoxybenzyl)-4-methyl-D-glycero-D-gluco-undecitol

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