4-[4'-(S)-'enzyloxycarbonyl-4'-(tert-butoxycarbonyl)aminobutyl]-1-[5''(S)-benzyloxycarbonyl-5''(tert-butoxycarbonyl)aminopentyl]-3,5-bis[3'''-(S)-(tert-butoxycarbonyl)amino-3'''-carboxypropyl]pyridinium

Base Information

Chemical Name:4-[4'-(S)-'enzyloxycarbonyl-4'-(tert-butoxycarbonyl)aminobutyl]-1-[5''(S)-benzyloxycarbonyl-5''(tert-butoxycarbonyl)aminopentyl]-3,5-bis[3'''-(S)-(tert-butoxycarbonyl)amino-3'''-carboxypropyl]pyridinium
CAS No.:1364376-05-5
Molecular Formula:C₅₈H₈₄N₅O₁₆
Molecular Weight:1107.33
Hs Code.:

4-[4'-(S)-'enzyloxycarbonyl-4'-(tert-butoxycarbonyl)aminobutyl]-1-[5''(S)-benzyloxycarbonyl-5''(tert-butoxycarbonyl)aminopentyl]-3,5-bis[3'''-(S)-(tert-butoxycarbonyl)amino-3'''-carboxypropyl]pyridinium

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Chemical Property of 4-[4'-(S)-'enzyloxycarbonyl-4'-(tert-butoxycarbonyl)aminobutyl]-1-[5''(S)-benzyloxycarbonyl-5''(tert-butoxycarbonyl)aminopentyl]-3,5-bis[3'''-(S)-(tert-butoxycarbonyl)amino-3'''-carboxypropyl]pyridinium

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Technology Process of 4-[4'-(S)-'enzyloxycarbonyl-4'-(tert-butoxycarbonyl)aminobutyl]-1-[5''(S)-benzyloxycarbonyl-5''(tert-butoxycarbonyl)aminopentyl]-3,5-bis[3'''-(S)-(tert-butoxycarbonyl)amino-3'''-carboxypropyl]pyridinium

There total 13 articles about 4-[4'-(S)-'enzyloxycarbonyl-4'-(tert-butoxycarbonyl)aminobutyl]-1-[5''(S)-benzyloxycarbonyl-5''(tert-butoxycarbonyl)aminopentyl]-3,5-bis[3'''-(S)-(tert-butoxycarbonyl)amino-3'''-carboxypropyl]pyridinium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1310077-21-4
benzyl 2-(S)-((tert-butoxycarbonyl)amino)-6-iodo-hexanoate

: 1364376-02-2
4,4'-{4-[(S)-4-benzyloxycarbonyl-4-(tert-butoxycarbonyl)aminobutyl]pyridin-3,5-diyl}di[(S)-2-(tert-butoxycarbonyl)aminobutanoic acid]

: 1364376-05-5
4-[4'-(S)-'enzyloxycarbonyl-4'-(tert-butoxycarbonyl)aminobutyl]-1-[5''(S)-benzyloxycarbonyl-5''(tert-butoxycarbonyl)aminopentyl]-3,5-bis[3'''-(S)-(tert-butoxycarbonyl)amino-3'''-carboxypropyl]pyridinium

Guidance literature:: In nitromethane; at 50 - 65 ℃; for 99.5h; Inert atmosphere;
DOI:10.1039/c2cc17958j

Reference yield:

: 936242-42-1
(S)-2-((tert-butoxycarbonyl)amino)-4-pentynoic acid benzyl ester

: 1364376-05-5
4-[4'-(S)-'enzyloxycarbonyl-4'-(tert-butoxycarbonyl)aminobutyl]-1-[5''(S)-benzyloxycarbonyl-5''(tert-butoxycarbonyl)aminopentyl]-3,5-bis[3'''-(S)-(tert-butoxycarbonyl)amino-3'''-carboxypropyl]pyridinium

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(l) iodide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 8.5 h / 20 °C / Inert atmosphere

2.1: hydrogen; palladium / methanol / 96 h / 20 °C

3.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 16 h / -20 - 20 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / methanol / 48 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

5.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

6.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 20 °C / Inert atmosphere

7.1: nitromethane / 99.5 h / 50 - 65 °C / Inert atmosphere

With sodium chlorite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; trifuran-2-yl-phosphane; hydrogen; tetra-(n-butyl)ammonium iodide; caesium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; palladium; N-ethyl-N,N-diisopropylamine; In methanol; nitromethane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1.1: Sonogashira coupling;
DOI:10.1039/c2cc17958j

Reference yield:

: 1364376-24-8
3,5-bis{[(S)-2,2-dimethyl-3-tert-buthoxycarbonyl-1,3-oxazolidin-4-yl]ethynyl}-4-iodopyridine

: 1364376-05-5
4-[4'-(S)-'enzyloxycarbonyl-4'-(tert-butoxycarbonyl)aminobutyl]-1-[5''(S)-benzyloxycarbonyl-5''(tert-butoxycarbonyl)aminopentyl]-3,5-bis[3'''-(S)-(tert-butoxycarbonyl)amino-3'''-carboxypropyl]pyridinium

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(l) iodide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 8.5 h / 20 °C / Inert atmosphere

2.1: hydrogen; palladium / methanol / 96 h / 20 °C

3.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 16 h / -20 - 20 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / methanol / 48 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

5.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

6.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 20 °C / Inert atmosphere

7.1: nitromethane / 99.5 h / 50 - 65 °C / Inert atmosphere

With sodium chlorite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; trifuran-2-yl-phosphane; hydrogen; tetra-(n-butyl)ammonium iodide; caesium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; palladium; N-ethyl-N,N-diisopropylamine; In methanol; nitromethane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1.1: Sonogashira coupling;
DOI:10.1039/c2cc17958j