benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-{bis[2''(S)-(2''',2'''-dimethyl-3'''-(tert-butoxycarbonyl)-4'''-oxazolidin)ethyn-1''-yl]pyridin-3',5'-yl}pent-4-ynoate

Base Information

• Chemical Name: benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-{bis[2''(S)-(2''',2'''-dimethyl-3'''-(tert-butoxycarbonyl)-4'''-oxazolidin)ethyn-1''-yl]pyridin-3',5'-yl}pent-4-ynoate
• CAS No.: 1364375-60-9
• Molecular Formula: C₄₆H₅₈N₄O₁₀
• Molecular Weight: 826.987
• Mol file: 1364375-60-9.mol

Synonyms:benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-{bis[2''(S)-(2''',2'''-dimethyl-3'''-(tert-butoxycarbonyl)-4'''-oxazolidin)ethyn-1''-yl]pyridin-3',5'-yl}pent-4-ynoate

Chemical Property of benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-{bis[2''(S)-(2''',2'''-dimethyl-3'''-(tert-butoxycarbonyl)-4'''-oxazolidin)ethyn-1''-yl]pyridin-3',5'-yl}pent-4-ynoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-{bis[2''(S)-(2''',2'''-dimethyl-3'''-(tert-butoxycarbonyl)-4'''-oxazolidin)ethyn-1''-yl]pyridin-3',5'-yl}pent-4-ynoate

There total 7 articles about benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-{bis[2''(S)-(2''',2'''-dimethyl-3'''-(tert-butoxycarbonyl)-4'''-oxazolidin)ethyn-1''-yl]pyridin-3',5'-yl}pent-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(S)-2-((tert-butoxycarbonyl)amino)-4-pentynoic acid benzyl ester (936242-42-1) + 3,5-bis{[(S)-2,2-dimethyl-3-tert-buthoxycarbonyl-1,3-oxazolidin-4-yl]ethynyl}-4-iodopyridine (1364376-24-8) → benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-{bis[2''(S)-(2''',2'''-dimethyl-3'''-(tert-butoxycarbonyl)-4'''-oxazolidin)ethyn-1''-yl]pyridin-3',5'-yl}pent-4-ynoate (1364375-60-9)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; trifuran-2-yl-phosphane; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 8.5h; regioselective reaction; Inert atmosphere;

DOI:10.1039/c2cc17958j

Reference yield:

pyridin-4-ol (626-64-2,157061-69-3) → benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-{bis[2''(S)-(2''',2'''-dimethyl-3'''-(tert-butoxycarbonyl)-4'''-oxazolidin)ethyn-1''-yl]pyridin-3',5'-yl}pent-4-ynoate (1364375-60-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium acetate; sodium hydroxide / water / Reflux; Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: phosphorus tribromide / ethyl acetate / 4.5 h / 145 °C / Inert atmosphere

3.1: hydrogenchloride / tetrahydrofuran; diethyl ether; water / 0.08 h / 20 °C / Inert atmosphere

3.2: 24 h / Inert atmosphere; Reflux

4.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 30 h / 45 °C / Inert atmosphere

5.1: copper(l) iodide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 8.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifuran-2-yl-phosphane; sodium acetate; phosphorus tribromide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide; 4.1: Sonogashira coupling / 5.1: Sonogashira coupling;

DOI:10.1039/c2cc17958j

Reference yield:

4-hydroxy-3,5-diiodopyridine (7153-08-4) → benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-{bis[2''(S)-(2''',2'''-dimethyl-3'''-(tert-butoxycarbonyl)-4'''-oxazolidin)ethyn-1''-yl]pyridin-3',5'-yl}pent-4-ynoate (1364375-60-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: phosphorus tribromide / ethyl acetate / 4.5 h / 145 °C / Inert atmosphere

2.1: hydrogenchloride / tetrahydrofuran; diethyl ether; water / 0.08 h / 20 °C / Inert atmosphere

2.2: 24 h / Inert atmosphere; Reflux

3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 30 h / 45 °C / Inert atmosphere

4.1: copper(l) iodide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 8.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifuran-2-yl-phosphane; phosphorus tribromide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide; 3.1: Sonogashira coupling / 4.1: Sonogashira coupling;

DOI:10.1039/c2cc17958j

upstream raw materials:

pyridin-4-ol

3,4,5-triiodopyridine

4-hydroxy-3,5-diiodopyridine

benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-(trimethylsilyl)pent-4-ynoate

Downstream raw materials:

desmosine

4-[4'-(S)-'enzyloxycarbonyl-4'-(tert-butoxycarbonyl)aminobutyl]-1-[5''(S)-benzyloxycarbonyl-5''(tert-butoxycarbonyl)aminopentyl]-3,5-bis[3'''-(S)-(tert-butoxycarbonyl)amino-3'''-carboxypropyl]pyridinium

4,4'-{4-[(S)-4-benzyloxycarbonyl-4-(tert-butoxycarbonyl)aminobutyl]pyridin-3,5-diyl}di[(S)-2-(tert-butoxycarbonyl)aminobutanoic acid]

benzyl (S)-2-(tert-butoxycarbonyl)amino-5-{3,5-bis[(S)-3-(tert-butoxycarbonyl)amino-4-hydroxybutyl]pyridin-4-yl}pentanoate