C₄₆H₇₂O₅Si₂

Base Information

• Chemical Name: C₄₆H₇₂O₅Si₂
• CAS No.: 1429412-77-0
• Molecular Formula: C₄₆H₇₂O₅Si₂
• Molecular Weight: 761.246
• Mol file: 1429412-77-0.mol

Synonyms:

Chemical Property of C₄₆H₇₂O₅Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₆H₇₂O₅Si₂

There total 28 articles about C₄₆H₇₂O₅Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C45H68O5Si2 (1429412-72-5) + methyl iodide (74-88-4) → C46H72O5Si2 (1429412-76-9) + C46H72O5Si2 (1429412-77-0)

Guidance literature:

C₄₅H₆₈O₅Si₂; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride; In hexane; for 1h;

With methyllithium; copper(l) cyanide; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h;

methyl iodide; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; Overall yield = 72 mg;

DOI:10.1039/c3ob27508f

Reference yield:

2,2-Dimethyl-1,3-propanediol (126-30-7) → C46H72O5Si2 (1429412-76-9) + C46H72O5Si2 (1429412-77-0)

Guidance literature:

Multi-step reaction with 11 steps

1.1: sodium hydride / nujol; tetrahydrofuran / 16.5 h / 0 °C

1.2: 3.3 h / 0 °C

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 6 h / Reflux

3.1: (R)-Tol-BINAP; tetrabutylammonium triphenyldifluorosilicate; copper(II) bis(trifluoromethanesulfonate) / tetrahydrofuran / 16 h / -78 °C

4.1: methanol; toluene / 1 h / 110 °C / Sealed tube

5.1: potassium carbonate / acetone / 5 h

6.1: hydrogen / isopropyl alcohol / 6 h / 20 °C

7.1: trimethylaluminum / toluene; dichloromethane / 0.58 h / 0 °C

7.2: 1.17 h / 0 °C

8.1: 2,6-dimethylpyridine / dichloromethane / 0.25 h / 0 °C

9.1: triethylamine; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; copper(l) iodide; triphenylphosphine / N,N-dimethyl-formamide / 9 h / 60 °C

10.1: chloro {[(1S,2S)-(-)-2-amino-1,2-diphenylethyl](4-toluenesulfonyl)amido}(mesitylene)ruthenium(II); sodium formate; 1-butyl-3-methylimidazolium Tetrafluoroborate / ethyl acetate; water / 7 h / 20 °C

11.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride / hexane / 1 h

11.2: 1 h / -78 °C

11.3: -78 - 20 °C

With 2,6-dimethylpyridine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; chloro {[(1S,2S)-(-)-2-amino-1,2-diphenylethyl](4-toluenesulfonyl)amido}(mesitylene)ruthenium(II); palladium bis[bis(diphenylphosphino)ferrocene] dichloride; (R)-Tol-BINAP; hydrogen; trimethylaluminum; tri-n-butyl-tin hydride; sodium formate; copper(II) bis(trifluoromethanesulfonate); sodium hydride; potassium carbonate; triethylamine; triphenylphosphine; tetrabutylammonium triphenyldifluorosilicate; 1-butyl-3-methylimidazolium Tetrafluoroborate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; nujol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetone; toluene; 3.1: |Mukaiyama Aldol Addition / 10.1: |Noyori Asymmetric Hydrogenation;

DOI:10.1039/c3ob27508f

Reference yield:

C28H38O5Si (1429412-35-0) → C46H72O5Si2 (1429412-76-9) + C46H72O5Si2 (1429412-77-0)

Guidance literature:

Multi-step reaction with 8 steps

1.1: methanol; toluene / 1 h / 110 °C / Sealed tube

2.1: potassium carbonate / acetone / 5 h

3.1: hydrogen / isopropyl alcohol / 6 h / 20 °C

4.1: trimethylaluminum / toluene; dichloromethane / 0.58 h / 0 °C

4.2: 1.17 h / 0 °C

5.1: 2,6-dimethylpyridine / dichloromethane / 0.25 h / 0 °C

6.1: triethylamine; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; copper(l) iodide; triphenylphosphine / N,N-dimethyl-formamide / 9 h / 60 °C

7.1: chloro {[(1S,2S)-(-)-2-amino-1,2-diphenylethyl](4-toluenesulfonyl)amido}(mesitylene)ruthenium(II); sodium formate; 1-butyl-3-methylimidazolium Tetrafluoroborate / ethyl acetate; water / 7 h / 20 °C

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride / hexane / 1 h

8.2: 1 h / -78 °C

8.3: -78 - 20 °C

With 2,6-dimethylpyridine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; chloro {[(1S,2S)-(-)-2-amino-1,2-diphenylethyl](4-toluenesulfonyl)amido}(mesitylene)ruthenium(II); palladium bis[bis(diphenylphosphino)ferrocene] dichloride; hydrogen; trimethylaluminum; tri-n-butyl-tin hydride; sodium formate; potassium carbonate; triethylamine; triphenylphosphine; 1-butyl-3-methylimidazolium Tetrafluoroborate; In methanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetone; toluene; 7.1: |Noyori Asymmetric Hydrogenation;

DOI:10.1039/c3ob27508f

upstream raw materials:

C₂₈H₃₈O₅Si

C₂₆H₃₆O₅Si

C₂₅H₃₂O₄Si

2,2-Dimethyl-1,3-propanediol