Ethyl 2-(4-chlorophenoxy)acetoacetate

Base Information

• Chemical Name: Ethyl 2-(4-chlorophenoxy)acetoacetate
• CAS No.: 119138-47-5
• Molecular Formula: C12H13ClO4
• Molecular Weight: 256.68200
• Hs Code.: 2918990090
• Mol file: 119138-47-5.mol

Synonyms:

Chemical Property of Ethyl 2-(4-chlorophenoxy)acetoacetate

Chemical Property:

• PSA: 52.60000
• LogP: 2.23950

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl2-(4-Chlorophenoxy)acetoacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-(4-chlorophenoxy)acetoacetate

There total 6 articles about Ethyl 2-(4-chlorophenoxy)acetoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

sodium 4-chlorophenolate (1193-00-6) + ethyl 2-chloro-3-oxo-butyrate (609-15-4) → ethyl 2-(4-chlorophenoxy)-3-oxobutanoate (119138-47-5)

Guidance literature:

at 80 ℃; for 5h;

DOI:10.1016/j.ejmech.2004.09.018

Reference yield:

ethyl (2-chloroaceto)acetate (638-07-3) + 4-chloro-phenol (106-48-9,82344-39-6) → ethyl 2-(4-chlorophenoxy)-3-oxobutanoate (119138-47-5)

Guidance literature:

In toluene; mineral oil;

Reference yield:

4-chloro-phenol (106-48-9,82344-39-6) + ethyl 2-chloro-3-oxo-butyrate (609-15-4) → ethyl 2-(4-chlorophenoxy)-3-oxobutanoate (119138-47-5)

Guidance literature:

With sodium hydride; mineral oil; In benzene; 1) 10 h then reflux, 30 min; 2) reflux, 10 h;

DOI:10.1002/mrc.1260260615

upstream raw materials:

4-chloro-phenol

ethyl 2-chloro-3-oxo-butyrate

sodium 4-chlorophenolate

ethyl acetoacetate

Downstream raw materials:

ethyl 2-(4-chlorophenoxy)-2-methyl-3-hydroxy-butanoate

C₂₀H₁₃ClO₃

C₁₆H₁₀Cl₂O₄

4-methyl-7-hydroxy-3-(4-chlorophenoxy)-2H-1-benzopyran-2-one

Refernces

• 1、 Rathnam,Thatte, Chittaranjan S.,Pise, Abhinay C.. "Ion exchange resin catalyzed synthesis of substituted-4-methyl-3-(substituted phenoxy)coumarins". body text. p. 6092 - 6098. Retrieved 2010/12/19.
• 2、 -. "Alpha-adrenergic receptor antagonists". . . Retrieved 2008/06/13.