Toluene-4-sulfonic acid 6-[4-acetyl-1-benzyl-5-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-benzyl)-3,6-dioxo-piperazin-(2Z)-ylidenemethyl]-4-methyl-benzo[1,3]dioxol-5-yl ester

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Chemical Name:Toluene-4-sulfonic acid 6-[4-acetyl-1-benzyl-5-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-benzyl)-3,6-dioxo-piperazin-(2Z)-ylidenemethyl]-4-methyl-benzo[1,3]dioxol-5-yl ester
CAS No.:628718-30-9
Molecular Formula:C₄₀H₃₉BrN₂O₁₁S
Molecular Weight:835.726
Hs Code.:

Toluene-4-sulfonic acid 6-[4-acetyl-1-benzyl-5-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-benzyl)-3,6-dioxo-piperazin-(2Z)-ylidenemethyl]-4-methyl-benzo[1,3]dioxol-5-yl ester

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Chemical Property of Toluene-4-sulfonic acid 6-[4-acetyl-1-benzyl-5-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-benzyl)-3,6-dioxo-piperazin-(2Z)-ylidenemethyl]-4-methyl-benzo[1,3]dioxol-5-yl ester

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Technology Process of Toluene-4-sulfonic acid 6-[4-acetyl-1-benzyl-5-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-benzyl)-3,6-dioxo-piperazin-(2Z)-ylidenemethyl]-4-methyl-benzo[1,3]dioxol-5-yl ester

There total 9 articles about Toluene-4-sulfonic acid 6-[4-acetyl-1-benzyl-5-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-benzyl)-3,6-dioxo-piperazin-(2Z)-ylidenemethyl]-4-methyl-benzo[1,3]dioxol-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 287117-31-1
2-bromo-5-hydroxy-4-methoxy-3-methylbenzaldehyde

: 628718-30-9
Toluene-4-sulfonic acid 6-[4-acetyl-1-benzyl-5-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-benzyl)-3,6-dioxo-piperazin-(2Z)-ylidenemethyl]-4-methyl-benzo[1,3]dioxol-5-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 100 percent / K₂CO₃ / dimethylformamide / 1 h / 25 °C

2.1: 6.749 g / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 1 h / 25 °C

3.1: 100 percent / H₂ / Rh/C / propan-2-ol / 19 h / 760 Torr

4.1: 4.106 g / pyridine; DMAP / 1 h / 25 °C

5.1: 72.9 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 2 h / 25 °C

6.1: NaH / dimethylformamide / 0 °C

6.2: dimethylformamide / 24 h / 25 °C

With pyridine; dmap; potassium tert-butylate; hydrogen; sodium hydride; potassium carbonate; Rh on carbon; In N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol;
DOI:10.1248/cpb.51.821

Reference yield:

: 628718-95-6
2-bromo-4-methoxy-5-methoxymethoxy-3-methylbenzaldehyde

: 628718-30-9
Toluene-4-sulfonic acid 6-[4-acetyl-1-benzyl-5-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-benzyl)-3,6-dioxo-piperazin-(2Z)-ylidenemethyl]-4-methyl-benzo[1,3]dioxol-5-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 6.749 g / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 1 h / 25 °C

2.1: 100 percent / H₂ / Rh/C / propan-2-ol / 19 h / 760 Torr

3.1: 4.106 g / pyridine; DMAP / 1 h / 25 °C

4.1: 72.9 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 2 h / 25 °C

5.1: NaH / dimethylformamide / 0 °C

5.2: dimethylformamide / 24 h / 25 °C

With pyridine; dmap; potassium tert-butylate; hydrogen; sodium hydride; Rh on carbon; In N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol;
DOI:10.1248/cpb.51.821

Reference yield:

: 628718-04-7
1-Acetyl-3-[1-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-phenyl)-meth-(Z)-ylidene]-piperazine-2,5-dione

: 628718-30-9
Toluene-4-sulfonic acid 6-[4-acetyl-1-benzyl-5-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-benzyl)-3,6-dioxo-piperazin-(2Z)-ylidenemethyl]-4-methyl-benzo[1,3]dioxol-5-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / H₂ / Rh/C / propan-2-ol / 19 h / 760 Torr

2.1: 4.106 g / pyridine; DMAP / 1 h / 25 °C

3.1: 72.9 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 2 h / 25 °C

4.1: NaH / dimethylformamide / 0 °C

4.2: dimethylformamide / 24 h / 25 °C

With pyridine; dmap; potassium tert-butylate; hydrogen; sodium hydride; Rh on carbon; In N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol;
DOI:10.1248/cpb.51.821