1-Acetyl-3-[1-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-phenyl)-meth-(Z)-ylidene]-piperazine-2,5-dione

Base Information

• Chemical Name: 1-Acetyl-3-[1-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-phenyl)-meth-(Z)-ylidene]-piperazine-2,5-dione
• CAS No.: 628718-04-7
• Molecular Formula: C₁₇H₁₉BrN₂O₆
• Molecular Weight: 427.252

Synonyms:1-Acetyl-3-[1-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-phenyl)-meth-(Z)-ylidene]-piperazine-2,5-dione

Chemical Property of 1-Acetyl-3-[1-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-phenyl)-meth-(Z)-ylidene]-piperazine-2,5-dione

Chemical Property:

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Technology Process of 1-Acetyl-3-[1-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-phenyl)-meth-(Z)-ylidene]-piperazine-2,5-dione

There total 2 articles about 1-Acetyl-3-[1-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-phenyl)-meth-(Z)-ylidene]-piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N'-diacetylpiperazin-2,5-dione (3027-05-2) + 2-bromo-4-methoxy-5-methoxymethoxy-3-methylbenzaldehyde (628718-95-6) → 1-Acetyl-3-[1-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-phenyl)-meth-(Z)-ylidene]-piperazine-2,5-dione (628718-04-7)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; tert-butyl alcohol; at 25 ℃; for 1h;

DOI:10.1248/cpb.51.821

Reference yield:

2-bromo-5-hydroxy-4-methoxy-3-methylbenzaldehyde (287117-31-1) → 1-Acetyl-3-[1-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-phenyl)-meth-(Z)-ylidene]-piperazine-2,5-dione (628718-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / K₂CO₃ / dimethylformamide / 1 h / 25 °C

2: 6.749 g / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 1 h / 25 °C

With potassium tert-butylate; potassium carbonate; In N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1248/cpb.51.821

Reference yield: 100.0%

1-Acetyl-3-[1-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-phenyl)-meth-(Z)-ylidene]-piperazine-2,5-dione (628718-04-7) → 1-acetyl-3-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-benzyl)-piperazine-2,5-dione (628718-11-6)

Guidance literature:

With hydrogen; Rh on carbon; In isopropyl alcohol; for 19h; under 760 Torr;

DOI:10.1248/cpb.51.821

upstream raw materials:

N,N'-diacetylpiperazin-2,5-dione

2-bromo-4-methoxy-5-methoxymethoxy-3-methylbenzaldehyde

2-bromo-5-hydroxy-4-methoxy-3-methylbenzaldehyde

Downstream raw materials:

1-acetyl-3-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-benzyl)-piperazine-2,5-dione

1,4-diacetyl-3-(2-bromo-4-methoxy-5-methoxymethoxy-3-methylphenylmethyl)-2,5-piperazinedione

(Z)-1-acetyl-6-(2-bromo-4-methoxy-5-methoxymethoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]piperazine-2,5-dione

Toluene-4-sulfonic acid 6-[1-benzyl-5-(2-bromo-4-methoxy-5-methoxymethoxy-3-methyl-benzyl)-3,6-dioxo-piperazin-(2Z)-ylidenemethyl]-4-methyl-benzo[1,3]dioxol-5-yl ester

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