(4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

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Chemical Name:(4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester
CAS No.:1026647-11-9
Molecular Formula:C₄₀H₄₆N₂O₁₀SSi
Molecular Weight:774.964
Hs Code.:

(4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

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Chemical Property of (4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

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Technology Process of (4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

There total 9 articles about (4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10147-36-1
n-propanesulfonyl chloride

: 1026426-92-5
(4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(7-hydroxymethyl-9-oxo-9H-fluoren-3-yl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

: 1026647-11-9
(4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: With triethylamine; In dichloromethane; at -20 ℃; for 0.5h;
DOI:10.1021/jo980381n

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 1026647-11-9
(4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) BCl₃, 2.) AlCl₃ / 1.) PhCl, room temperature, 1 h, 2.) 130-140 deg C, 2 h

2: 73 percent / superphosphoric acid, NaNO₂ / chlorobenzene / 2 h / 80 - 82 °C

3: 90 percent / NBS, AcOH, 2,2'-azobis(2,4-dimethylvaleronitrile) / CH₂Cl₂ / 12 h / Heating

4: 24 h / 100 °C

5: 92 percent / conc. H₂SO₄ / methanol / 1.5 h / 60 °C

7: Et₃N / CH₂Cl₂ / 0.5 h / -20 °C

With N-Bromosuccinimide; aluminium trichloride; superphosphoric acid; 2,2'-azobis-(2,4-dimethylvaleronitrile); sulfuric acid; boron trichloride; acetic acid; triethylamine; sodium nitrite; In methanol; dichloromethane; chlorobenzene;
DOI:10.1021/jo980381n

Reference yield:

: 91713-57-4
(2-amino-5-methylphenyl)(4-bromophenyl)methanone

: 1026647-11-9
(4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 73 percent / superphosphoric acid, NaNO₂ / chlorobenzene / 2 h / 80 - 82 °C

2: 90 percent / NBS, AcOH, 2,2'-azobis(2,4-dimethylvaleronitrile) / CH₂Cl₂ / 12 h / Heating

3: 24 h / 100 °C

4: 92 percent / conc. H₂SO₄ / methanol / 1.5 h / 60 °C

6: Et₃N / CH₂Cl₂ / 0.5 h / -20 °C

With N-Bromosuccinimide; superphosphoric acid; 2,2'-azobis-(2,4-dimethylvaleronitrile); sulfuric acid; acetic acid; triethylamine; sodium nitrite; In methanol; dichloromethane; chlorobenzene;
DOI:10.1021/jo980381n