91713-57-4

Upstream product

• 623-00-7 4-bromobenzenecarbonitrile 
• 106-49-0 p-toluidine 

Downstream Products

• 91741-90-1 Sodium; [2-amino-3-(4-bromo-benzoyl)-5-methyl-phenyl]-acetate 
• 91714-12-4 7-(4-Bromo-benzoyl)-5-methyl-3-methylsulfanyl-1,3-dihydro-indol-2-one 
• 91714-13-5 7-(4-Bromo-benzoyl)-5-methyl-1,3-dihydro-indol-2-one 
• 169957-63-5 [4S-(4α,5β,6β(S*))]-1-(2-amino-2-oxoethyl)-4-({6-[2-carboxy-6-(1-hydroxyethyl)4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]-9-oxo-9H-fluoren-2-yl}methyl)-1,4-diazaniabicyclo[2.2.2]octane chloride 
• 757171-36-1 1-{6-[(4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-2-(4-nitro-benzyloxycarbonyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-en-3-yl]-9-oxo-9H-fluoren-2-ylmethyl}-4-aza-1-azonia-bicyclo[2.2.2]octane 
• 212691-56-0 (4S,5R,6S)-4-Methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 1026647-11-9 (4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 169552-95-8 (4S,5R,6S)-4-Methyl-7-oxo-3-(9-oxo-7-trimethylsilanyloxymethyl-9H-fluoren-3-yl)-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 157743-80-1 (4S,5R,6S)-3-(7-Hydroxymethyl-9-oxo-9H-fluoren-3-yl)-4-methyl-7-oxo-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 1026426-92-5 (4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(7-hydroxymethyl-9-oxo-9H-fluoren-3-yl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

In situ NMR spectroscopic studies of aniline ortho acylation ("sugasawa reaction"): The nature of reaction intermediates and Lewis acid influence on yield

Ortho acylation of anilines by nitriles in the presence of BCl3 and a second Lewis acid appear to proceed through an intermediate "supercomplex" including all four components. Yield improvements were obtained based on recognition that chloride affinity of the second Lewis acid governs supercomplex formation. Aniline protonation was found to be the cause of incomplete reaction.

Practical synthesis of anti-methicillin-resistant Staphylococcus aureus (MRSA) carbapenem L-742,728

Anti-MRSA carbapenem, L-742,728, has been prepared in large quantity using the Suzuki-Miyaura cross-coupling as the key reaction. Three approaches have been examined by varying the coupling reaction between carbapenem nucleus A and side chains B, BC, and