(4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(7-hydroxymethyl-9-oxo-9H-fluoren-3-yl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Base Information

Chemical Name:(4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(7-hydroxymethyl-9-oxo-9H-fluoren-3-yl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester
CAS No.:1026426-92-5
Molecular Formula:C₃₇H₄₀N₂O₈Si
Molecular Weight:668.819
Hs Code.:

(4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(7-hydroxymethyl-9-oxo-9H-fluoren-3-yl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

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Chemical Property of (4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(7-hydroxymethyl-9-oxo-9H-fluoren-3-yl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

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Technology Process of (4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(7-hydroxymethyl-9-oxo-9H-fluoren-3-yl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

There total 8 articles about (4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(7-hydroxymethyl-9-oxo-9H-fluoren-3-yl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 623-00-7
4-bromobenzenecarbonitrile

: 1026426-92-5
(4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(7-hydroxymethyl-9-oxo-9H-fluoren-3-yl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) BCl₃, 2.) AlCl₃ / 1.) PhCl, room temperature, 1 h, 2.) 130-140 deg C, 2 h

2: 73 percent / superphosphoric acid, NaNO₂ / chlorobenzene / 2 h / 80 - 82 °C

3: 90 percent / NBS, AcOH, 2,2'-azobis(2,4-dimethylvaleronitrile) / CH₂Cl₂ / 12 h / Heating

4: 24 h / 100 °C

5: 92 percent / conc. H₂SO₄ / methanol / 1.5 h / 60 °C

With N-Bromosuccinimide; aluminium trichloride; superphosphoric acid; 2,2'-azobis-(2,4-dimethylvaleronitrile); sulfuric acid; boron trichloride; acetic acid; sodium nitrite; In methanol; dichloromethane; chlorobenzene;
DOI:10.1021/jo980381n

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 1026426-92-5
(4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(7-hydroxymethyl-9-oxo-9H-fluoren-3-yl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) BCl₃, 2.) AlCl₃ / 1.) PhCl, room temperature, 1 h, 2.) 130-140 deg C, 2 h

2: 73 percent / superphosphoric acid, NaNO₂ / chlorobenzene / 2 h / 80 - 82 °C

3: 90 percent / NBS, AcOH, 2,2'-azobis(2,4-dimethylvaleronitrile) / CH₂Cl₂ / 12 h / Heating

4: 24 h / 100 °C

5: 92 percent / conc. H₂SO₄ / methanol / 1.5 h / 60 °C

With N-Bromosuccinimide; aluminium trichloride; superphosphoric acid; 2,2'-azobis-(2,4-dimethylvaleronitrile); sulfuric acid; boron trichloride; acetic acid; sodium nitrite; In methanol; dichloromethane; chlorobenzene;
DOI:10.1021/jo980381n

Reference yield:

: 91713-57-4
(2-amino-5-methylphenyl)(4-bromophenyl)methanone

: 1026426-92-5
(4S,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(7-hydroxymethyl-9-oxo-9H-fluoren-3-yl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / superphosphoric acid, NaNO₂ / chlorobenzene / 2 h / 80 - 82 °C

2: 90 percent / NBS, AcOH, 2,2'-azobis(2,4-dimethylvaleronitrile) / CH₂Cl₂ / 12 h / Heating

3: 24 h / 100 °C

4: 92 percent / conc. H₂SO₄ / methanol / 1.5 h / 60 °C

With N-Bromosuccinimide; superphosphoric acid; 2,2'-azobis-(2,4-dimethylvaleronitrile); sulfuric acid; acetic acid; sodium nitrite; In methanol; dichloromethane; chlorobenzene;
DOI:10.1021/jo980381n