18,25-dihydroxyvitamin D₃

Base Information

Chemical Name:18,25-dihydroxyvitamin D₃
CAS No.:141245-45-6
Molecular Formula:C₂₇H₄₄O₃
Molecular Weight:416.645
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 18,25-dihydroxyvitamin D₃

Chemical Property:

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Technology Process of 18,25-dihydroxyvitamin D₃

There total 9 articles about 18,25-dihydroxyvitamin D₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 141245-55-8
(1R,3aS,7aS)-7a-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-indene

: 141245-45-6
18,25-dihydroxyvitamin D₃

Guidance literature:: With AG 50W-X₄; In methanol; for 144h; Ambient temperature;
DOI:10.1016/S0040-4039(00)91659-9

Reference yield:

: 135359-40-9
de-A,B-24-(methoxycarbonyl)-cholestan-8β-ol

: 141245-45-6
18,25-dihydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 9 steps

1: 62 percent / Pb(OAc)4 / benzene / 22 h / Heating

2: 95 percent / diethyl ether / -78 deg C to r.t.

3: 56 percent / NaIO₄, RuO₄*H₂O / CCl₄; H₂O; acetonitrile / 360 h / Ambient temperature

4: 98 percent / i-Pr₂NH, DMAP / CH₂Cl₂ / a) 0 deg C, 6 h, b) r.t., 12 h

5: 99 percent / diisobutylaluminum hydride (DIBAL-H) / tetrahydrofuran; toluene / a) -78 deg C, 15 min, b) -78 deg C to r.t.

6: 76 percent / imidazole / CH₂Cl₂; dimethylformamide / 1 h / Ambient temperature

7: 87 percent / pyridinium dichromate, PPTS / CH₂Cl₂ / a) 0 deg C, 1 h, b) r.t., 4 h

8: 87 percent / tetrahydrofuran / 1 h / -78 deg C to r.t.

9: 47 percent / AG 50W-X₄ / methanol / 144 h / Ambient temperature

With 1H-imidazole; lead(IV) acetate; dmap; sodium periodate; dipyridinium dichromate; ruthenium tetroxide; AG 50W-X₄; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; diisopropylamine; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;
DOI:10.1016/S0040-4039(00)91659-9

Reference yield:

: 141245-48-9
(R)-2-Methyl-6-(1S,2R,5R,6S)-11-oxa-tricyclo[4.3.2.0^1,5]undec-2-yl-heptan-2-ol

: 141245-45-6
18,25-dihydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 7 steps

1: 56 percent / NaIO₄, RuO₄*H₂O / CCl₄; H₂O; acetonitrile / 360 h / Ambient temperature

2: 98 percent / i-Pr₂NH, DMAP / CH₂Cl₂ / a) 0 deg C, 6 h, b) r.t., 12 h

3: 99 percent / diisobutylaluminum hydride (DIBAL-H) / tetrahydrofuran; toluene / a) -78 deg C, 15 min, b) -78 deg C to r.t.

4: 76 percent / imidazole / CH₂Cl₂; dimethylformamide / 1 h / Ambient temperature

5: 87 percent / pyridinium dichromate, PPTS / CH₂Cl₂ / a) 0 deg C, 1 h, b) r.t., 4 h

6: 87 percent / tetrahydrofuran / 1 h / -78 deg C to r.t.

7: 47 percent / AG 50W-X₄ / methanol / 144 h / Ambient temperature

With 1H-imidazole; dmap; sodium periodate; dipyridinium dichromate; ruthenium tetroxide; AG 50W-X₄; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; diisopropylamine; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0040-4039(00)91659-9