2R,5R-bis(diphenylphosphino)hexane

Base Information

• Chemical Name: 2R,5R-bis(diphenylphosphino)hexane
• CAS No.: 216019-41-9
• Molecular Formula: C₃₀H₃₂P₂
• Molecular Weight: 454.532
• Mol file: 216019-41-9.mol

Synonyms:

Chemical Property of 2R,5R-bis(diphenylphosphino)hexane

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2R,5R-bis(diphenylphosphino)hexane

There total 8 articles about 2R,5R-bis(diphenylphosphino)hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ ((2R,5R)-hexane-2,5-diyl)bis(diphenylphosphane) (216019-41-9,142494-67-5,175892-81-6)

Guidance literature:

With sodium hydrogencarbonate; tetrafluoroboric acid dimethyl ether complex; In dichloromethane; 1.) a.) -5 up to 25 deg C; b.) 25 deg C, 12h; 2.) 0 deg C, 10 min;

DOI:10.1016/0040-4020(95)00390-T

Reference yield: 70.0%

(2S,5S)-hexane-2,5-diol di-p-toluenesulfonate (17299-04-6) + lithium diphenylphosphide (65567-06-8,4541-02-0) → (2R,5R)-(+)-2,5-bis-(diphenylphosphino)hexane (216019-41-9,142494-67-5,175892-81-6)

Guidance literature:

In tetrahydrofuran; for 16h;

DOI:10.1016/0957-4166(96)00016-X

Reference yield: 67.0%

1,4-bis(methylsulfonyloxy)-1,4-dimethylbutane (55-93-6) + diphenylphosphane (829-85-6) → 2R,5R-bis(diphenylphosphino)hexane (216019-41-9,142494-67-5,175892-81-6)

Guidance literature:

diphenylphosphane; With n-butyllithium; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 1h; Inert atmosphere;

1,4-bis(methylsulfonyloxy)-1,4-dimethylbutane; In tetrahydrofuran; hexane; Inert atmosphere;

DOI:10.1246/bcsj.20210023

upstream raw materials:

(S,S)-2,5-bis(methylsulfonyloxy)hexane

diphenylphosphane

(2S,5S)-2,5-hexanediol

(2S,5S)-hexane-2,5-diol di-p-toluenesulfonate