Technology Process of D-6-O-benzyl-3-O-benzoyl-1,2-O-cyclohexylidene-4-deoxy-neoinositol
There total 12 articles about D-6-O-benzyl-3-O-benzoyl-1,2-O-cyclohexylidene-4-deoxy-neoinositol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 90 percent / H2SO4 / dimethylformamide / 12 h / Ambient temperature
2: 90 percent / triphenylphosphine, carbon tetrachloride, pyridine / 8 h / 60 °C
3: 1.) potassium hydroxide, benzyltrimethylammonium chloride / 1.) CH2Cl2, 10 min, 2.) CH2Cl2, 12 h
4: 60 percent / sodium hydride / dimethylformamide / 3 h / 110 °C
5: 1.) HgCl2, 2.) thiourea / 1.) acetone-d6, D2O, 20 min, 2.) acetone-d6, D2O
6: 30 percent / lithium tri-terbutoxyaluminiumhydride / tetrahydrofuran / -40 °C / other reagent: cerium(III) chloride heptahydrate, sodium borohydride
7: pyridine / 2 h
With
pyridine; tetrachloromethane; potassium hydroxide; sulfuric acid; benzyltrimethylammonium chloride; sodium hydride; lithium tri-t-butoxyaluminum hydride; thiourea; triphenylphosphine; mercury dichloride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)10101-6
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) potassium hydroxide, benzyltrimethylammonium chloride / 1.) CH2Cl2, 10 min, 2.) CH2Cl2, 12 h
2: 60 percent / sodium hydride / dimethylformamide / 3 h / 110 °C
3: 1.) HgCl2, 2.) thiourea / 1.) acetone-d6, D2O, 20 min, 2.) acetone-d6, D2O
4: 30 percent / lithium tri-terbutoxyaluminiumhydride / tetrahydrofuran / -40 °C / other reagent: cerium(III) chloride heptahydrate, sodium borohydride
5: pyridine / 2 h
With
pyridine; potassium hydroxide; benzyltrimethylammonium chloride; sodium hydride; lithium tri-t-butoxyaluminum hydride; thiourea; mercury dichloride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)10101-6
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 90 percent / triphenylphosphine, carbon tetrachloride, pyridine / 8 h / 60 °C
2: 1.) potassium hydroxide, benzyltrimethylammonium chloride / 1.) CH2Cl2, 10 min, 2.) CH2Cl2, 12 h
3: 60 percent / sodium hydride / dimethylformamide / 3 h / 110 °C
4: 1.) HgCl2, 2.) thiourea / 1.) acetone-d6, D2O, 20 min, 2.) acetone-d6, D2O
5: 30 percent / lithium tri-terbutoxyaluminiumhydride / tetrahydrofuran / -40 °C / other reagent: cerium(III) chloride heptahydrate, sodium borohydride
6: pyridine / 2 h
With
pyridine; tetrachloromethane; potassium hydroxide; benzyltrimethylammonium chloride; sodium hydride; lithium tri-t-butoxyaluminum hydride; thiourea; triphenylphosphine; mercury dichloride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)10101-6
