1-propyl-1H-pyrrolo[2,3-b]pyridine

Base Information

• Chemical Name: 1-propyl-1H-pyrrolo[2,3-b]pyridine
• CAS No.: 942262-52-4
• Molecular Formula: C₁₀H₁₂N₂
• Molecular Weight: 160.219
• Mol file: 942262-52-4.mol

Synonyms:

Chemical Property of 1-propyl-1H-pyrrolo[2,3-b]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-propyl-1H-pyrrolo[2,3-b]pyridine

There total 3 articles about 1-propyl-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

7-Azaindole (271-63-6) → N-propyl-7-azaindole (942262-52-4)

Guidance literature:

7-Azaindole; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

n-propyl halide; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

DOI:10.1248/cpb.55.255

Reference yield: 81.0%

7-Azaindole (271-63-6) + 1-iodo-propane (107-08-4) → N-propyl-7-azaindole (942262-52-4)

Guidance literature:

7-Azaindole; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

1-iodo-propane; In N,N-dimethyl-formamide; for 3h;

DOI:10.1021/acs.joc.9b00174

Reference yield:

5-bromo-1-propyl-1H-pyrrolo[2,3-b]pyridine (1440956-68-2) → N-propyl-7-azaindole (942262-52-4)

Guidance literature:

5-bromo-1-propyl-1H-pyrrolo[2,3-b]pyridine; With tert.-butyl lithium; In tetrahydrofuran; at -80 ℃; for 0.166667h; Schlenk technique; Inert atmosphere;

With methanol; In tetrahydrofuran; at -75 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1021/ol4010454

upstream raw materials:

7-Azaindole

5-bromo-1-propyl-1H-pyrrolo[2,3-b]pyridine

1-iodo-propane

Refernces

• 1、 Waldmann, Christopher,Schober, Otmar,Haufe, Guenter,Kopka, Klaus. "A closer look at the bromine-lithium exchange with tert-butyllithium in an aryl sulfonamide synthesis". supporting information. p. 2954 - 2957. Retrieved 2013/07/26.