Carbamic acid (3aR,6S,6aR)-2,2-dimethyl-5-[(R)-3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester

Base Information

• Chemical Name: Carbamic acid (3aR,6S,6aR)-2,2-dimethyl-5-[(R)-3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester
• CAS No.: 118226-59-8
• Molecular Formula: C₂₀H₂₆N₂O₆
• Molecular Weight: 390.436
• Mol file: 118226-59-8.mol

Synonyms:

Chemical Property of Carbamic acid (3aR,6S,6aR)-2,2-dimethyl-5-[(R)-3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid (3aR,6S,6aR)-2,2-dimethyl-5-[(R)-3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester

There total 4 articles about Carbamic acid (3aR,6S,6aR)-2,2-dimethyl-5-[(R)-3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

isocyanate de chlorosulfonyle (1189-71-5) + 5-(1,2-O-isopropylidene-α-D-xylo-tetrafuranos-4-yl)-3-(2,4,6-trimethylphenyl)-2-isoxazoline (118226-54-3) → Carbamic acid (3aR,6S,6aR)-2,2-dimethyl-5-[(R)-3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester (118226-59-8)

Guidance literature:

In tetrahydrofuran; for 5h; Ambient temperature;

DOI:10.1021/jo00265a016

Reference yield:

mesitylenecarbonitrile oxide (2904-57-6) → Carbamic acid (3aR,6S,6aR)-2,2-dimethyl-5-[(R)-3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester (118226-59-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / Ambient temperature

2: 42 percent / tetrahydrofuran / 5 h / Ambient temperature

In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo00265a016

Reference yield:

5,6-dideoxy-1,2-O-isopropylidene-α-D-xylo-hex-5-eno-furanose (7284-07-3) → Carbamic acid (3aR,6S,6aR)-2,2-dimethyl-5-[(R)-3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester (118226-59-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / Ambient temperature

2: 42 percent / tetrahydrofuran / 5 h / Ambient temperature

In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo00265a016

upstream raw materials:

isocyanate de chlorosulfonyle

5-(1,2-O-isopropylidene-α-D-xylo-tetrafuranos-4-yl)-3-(2,4,6-trimethylphenyl)-2-isoxazoline

Carbamic acid (3aR,5R,6S,6aR)-2,2-dimethyl-5-vinyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester

mesitylenecarbonitrile oxide