5-(1,2-O-isopropylidene-α-D-xylo-tetrafuranos-4-yl)-3-(2,4,6-trimethylphenyl)-2-isoxazoline

Base Information

• Chemical Name: 5-(1,2-O-isopropylidene-α-D-xylo-tetrafuranos-4-yl)-3-(2,4,6-trimethylphenyl)-2-isoxazoline
• CAS No.: 118226-54-3
• Molecular Formula: C₁₉H₂₅NO₅
• Molecular Weight: 347.411
• Mol file: 118226-54-3.mol

Synonyms:5-(1,2-O-isopropylidene-α-D-xylo-tetrafuranos-4-yl)-3-(2,4,6-trimethylphenyl)-2-isoxazoline

Chemical Property of 5-(1,2-O-isopropylidene-α-D-xylo-tetrafuranos-4-yl)-3-(2,4,6-trimethylphenyl)-2-isoxazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(1,2-O-isopropylidene-α-D-xylo-tetrafuranos-4-yl)-3-(2,4,6-trimethylphenyl)-2-isoxazoline

There total 2 articles about 5-(1,2-O-isopropylidene-α-D-xylo-tetrafuranos-4-yl)-3-(2,4,6-trimethylphenyl)-2-isoxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

mesitylenecarbonitrile oxide (2904-57-6) + 5,6-dideoxy-1,2-O-isopropylidene-α-D-xylo-hex-5-eno-furanose (7284-07-3) → Dimesitylfuroxane (16031-58-6) + 5-(1,2-O-isopropylidene-α-D-xylo-tetrafuranos-4-yl)-3-(2,4,6-trimethylphenyl)-2-isoxazoline (118226-54-3) + (3aR,5S,6S,6aR)-2,2-Dimethyl-5-[(S)-3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-tetrahydro-furo[2,3-d][1,3]dioxol-6-ol (118332-54-0)

Guidance literature:

With triethylamine; In diethyl ether; Ambient temperature;

DOI:10.1016/0008-6215(91)84091-R

Reference yield:

mesitylenecarbonitrile oxide (2904-57-6) + 5,6-dideoxy-1,2-O-isopropylidene-α-D-xylo-hex-5-eno-furanose (7284-07-3) → 5-(1,2-O-isopropylidene-α-D-xylo-tetrafuranos-4-yl)-3-(2,4,6-trimethylphenyl)-2-isoxazoline (118226-54-3) + (3aR,5S,6S,6aR)-2,2-Dimethyl-5-[(S)-3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-tetrahydro-furo[2,3-d][1,3]dioxol-6-ol (118332-54-0)

Guidance literature:

In diethyl ether; Ambient temperature;

DOI:10.1021/jo00265a016

Reference yield: 100.0%

acetic anhydride (108-24-7) + 5-(1,2-O-isopropylidene-α-D-xylo-tetrafuranos-4-yl)-3-(2,4,6-trimethylphenyl)-2-isoxazoline (118226-54-3) → Acetic acid (3aR,5S,6S,6aR)-2,2-dimethyl-5-[(R)-3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester (118226-57-6)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1021/jo00265a016

upstream raw materials:

mesitylenecarbonitrile oxide

5,6-dideoxy-1,2-O-isopropylidene-α-D-xylo-hex-5-eno-furanose

Downstream raw materials:

Sodium; (3aR,5S,6S,6aR)-2,2-dimethyl-5-[(R)-3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-tetrahydro-furo[2,3-d][1,3]dioxole-6-carbodithioate

Carbamic acid (3aR,6S,6aR)-2,2-dimethyl-5-[(R)-3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester

Acetic acid (3aR,5S,6S,6aR)-2,2-dimethyl-5-[(R)-3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester

(R)-5-((3aR,5S,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazole