AZD5153

Base Information

Chemical Name:AZD5153
CAS No.:1869912-39-9
Molecular Formula:C₂₅H₃₃N₇O₃
Molecular Weight:479.582
Hs Code.:
Mol file:1869912-39-9.mol

Synonyms:

Suppliers and Price of AZD5153

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
AZD5153 >98%
250 mg
$ 1300.00

Cayman Chemical
AZD 5153 ≥95%
10mg
$ 240.00

Cayman Chemical
AZD 5153 ≥95%
5mg
$ 143.00

Cayman Chemical
AZD 5153 ≥95%
1mg
$ 30.00

Cayman Chemical
AZD 5153 ≥95%
25mg
$ 488.00

ApexBio Technology
AZD5153
25mg
$ 677.00

American Custom Chemicals Corporation
AZD-5153 95.00%
5MG
$ 455.81

AK Scientific
(3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one
10mg
$ 424.00

Total 8 raw suppliers

Chemical Property of AZD5153

Chemical Property:

Solubility.:≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide

Purity/Quality:

99%, ^*data from raw suppliers

AZD5153 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description AZD 5153 an orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4 (IC50 = 5 nM). It can simultaneously bind two bromodomains in BRD4, which has been shown to increase antitumor activity in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B cell lymphoma.

Technology Process of AZD5153

There total 16 articles about AZD5153 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.4%

: 4-(1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenol

: (R)-4-(2-hydroxyethyl)-1,3-dimethylpiperazin-2-one

: 1869912-39-9
(3R)?4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3?b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one

Guidance literature:: With tributylphosphine; 1,1'-(Azodicarbonyl)dipiperidin; In dichloromethane; at 0 - 5 ℃; for 0.5h; Reagent/catalyst; Temperature; Inert atmosphere;

Reference yield:

: 6-chloro-3-methoxy-[1,2,4]triazolo[4,3-b]pyridazine

: C₁₉H₂₉N₃O₂

: 1869912-39-9
(S)-4-(2-(4-(1-(3-methoxy[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-piperidin-4-yl)phenoxy)ethyl)-1,3-dimethylpiperazin-2-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 20 - 80 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b00070

Reference yield:

: 1869912-48-0
4-(piperidine-4-yl)phenol hydrobromide

: 1869912-39-9
(3R)?4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3?b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / 18 h / 55 °C

2: tributylphosphine; 1,1'-(Azodicarbonyl)dipiperidin / dichloromethane / 0.5 h / 0 - 5 °C / Inert atmosphere

With tributylphosphine; 1,1'-(Azodicarbonyl)dipiperidin; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;