Technology Process of C24H24ClF3N2
There total 4 articles about C24H24ClF3N2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); sodium t-butanolate;
In
1,4-dioxane;
at 20 ℃;
for 16h;
Inert atmosphere;
Molecular sieve;
Heating;
DOI:10.1021/ol4030925
- Guidance literature:
-
Multi-step reaction with 3 steps
1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 24 h / 80 °C / Inert atmosphere
2: potassium carbonate; [Rh(OH)(cod)]2 / water; 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere; Heating
3: sodium t-butanolate; chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere; Molecular sieve; Heating
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; [Rh(OH)(cod)]2; chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); potassium carbonate; caesium carbonate; sodium t-butanolate;
In
tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/ol4030925
- Guidance literature:
-
Multi-step reaction with 4 steps
1: trimethylsilyl bromide / 15 h / 100 °C / Inert atmosphere
2: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 24 h / 80 °C / Inert atmosphere
3: potassium carbonate; [Rh(OH)(cod)]2 / water; 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere; Heating
4: sodium t-butanolate; chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere; Molecular sieve; Heating
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; [Rh(OH)(cod)]2; trimethylsilyl bromide; chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); potassium carbonate; caesium carbonate; sodium t-butanolate;
In
tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/ol4030925