ethyl N-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>-N-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-2-(4-chloro-3-sulfamylphenyl)-4(R)-thiazolidinecarboxylate

Base Information

Chemical Name:ethyl N-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>-N-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-2-(4-chloro-3-sulfamylphenyl)-4(R)-thiazolidinecarboxylate
CAS No.:126257-70-3
Molecular Formula:C₃₀H₃₅Cl₄N₃O₉S₂
Molecular Weight:787.567
Hs Code.:

ethyl N-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>-N-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-2-(4-chloro-3-sulfamylphenyl)-4(R)-thiazolidinecarboxylate

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Chemical Property of ethyl N-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>-N-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-2-(4-chloro-3-sulfamylphenyl)-4(R)-thiazolidinecarboxylate

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Technology Process of ethyl N-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>-N-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-2-(4-chloro-3-sulfamylphenyl)-4(R)-thiazolidinecarboxylate

There total 2 articles about ethyl N-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>-N-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-2-(4-chloro-3-sulfamylphenyl)-4(R)-thiazolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3279-81-0
2-chloro-5-formyl-benzenesulphonamide

: 126257-70-3,126373-66-8
ethyl N-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>-N-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-2-(4-chloro-3-sulfamylphenyl)-4(R)-thiazolidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / ethanol; H₂O / 0.25 h / Heating

2: Et₃N / CH₂Cl₂

With triethylamine; In ethanol; dichloromethane; water;
DOI:10.1021/jm00168a013

Reference yield:

: 92893-50-0
N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine

: 126257-70-3,126373-66-8
ethyl N-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>-N-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-2-(4-chloro-3-sulfamylphenyl)-4(R)-thiazolidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 3.5 h / Ambient temperature

2: Et₃N / CH₂Cl₂

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm00168a013

Reference yield:

: 126257-70-3,126373-66-8
ethyl N-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>-N-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-2-(4-chloro-3-sulfamylphenyl)-4(R)-thiazolidinecarboxylate

: 99876-74-1,126373-70-4,126373-71-5
N-[((1S)-1-carboxy-3-phenylpropyl)-L-alanyl]-2-(4-chloro-3-sulfamylphenyl)-4(R)-thiazolidinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.28 g / glacial HOAc, Zn / 22 h

2: 8.9 M aq. NaOH / methanol

With sodium hydroxide; acetic acid; zinc; In methanol;
DOI:10.1021/jm00168a013