3279-81-0

Upstream product

• 74-11-3 para-chlorobenzoic acid 
• 2494-79-3 4-chloro-3-(chlorosulfonyl)benzoic acid 
• 1205-30-7 4-chloro-3-sulphamoylbenzoic acid 
• 1211-77-4 3-sulfamoyl-4-chlorobenzoic acid ethyl ester 
• 104-88-1 4-chlorobenzaldehyde 
• 1939-76-0 4-chloro-3-sulfamoylbenzonitrile 
• 7440-02-0 nickel 
• 90196-34-2 2-chloro-5-(hydroxymethyl)benzenesulfonamide 
• 3306-64-7 N-Acetyl-2-chlor-5-diacetoxymethyl-benzolsulfonamid 

Downstream Products

• 3555-36-0 2-chloro-5-(1,1-dioxo-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-benzenesulfonamide 
• 1036881-20-5 (E)-2-chloro-N-dimethylaminomethylene-5-formyl-benzenesulfonamide 
• 1189543-98-3 2-chloro-5-[4-(3-methyl-butoxy)-benzoyl]-benzenesulfonamide 
• 1189544-04-4 2-chloro-5-(4-hexyloxy-benzoyl)-benzenesulfonamide 
• 1189543-94-9 2-chloro-5-(4-butoxy-benzoyl)-benzenesulfonamide 
• 1189544-07-7 2-chloro-5-(4-trifluoromethoxy-benzoyl)-benzenesulfonamide 
• 1189544-02-2 2-chloro-5-(4-pentyloxy-benzoyl)-benzenesulfonamide 
• 1189545-72-9 2-chloro-5-{hydroxy-[4-(3-methyl-butoxy)-phenyl]-methyl}-benzenesulfonamide 
• 1189545-68-3 5-{[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-hydroxy-methyl}-2-chloro-benzenesulfonamide 
• 1189545-71-8 2-chloro-5-[hydroxy-(4-butoxy-phenyl)-methyl]-benzenesulfonamide 
• 1189545-77-4 2-chloro-5-[hydroxy-(4-trifluoromethoxy-phenyl)-methyl]-benzenesulfonamide 
• 1189545-75-2 2-chloro-5-[(4-pentyloxy-phenyl)-hydroxy-methyl]-benzenesulfonamide 
• 1189545-76-3 2-chloro-5-[(4-hexyloxy-phenyl)-hydroxy-methyl]-benzenesulfonamide 
• 126257-70-3 ethyl N-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>-N-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-2-(4-chloro-3-sulfamylphenyl)-4(R)-thiazolidinecarboxylate 

Relevant academic research and scientific papers

Synthesis of 3-Formylbenzenesulfonyl Chloride Derivatives

A synthetic route to 3-formylbenzenesulfonyl chloride derivatives from the corresponding benzaldehydes has been developed. The key step in this procedure is the conversion of aldehyde bisulfite adducts to target compounds via a two-stage reaction in the presence of Na 2 SO 4. A series of 3-formylbenzenesulfonyl chloride derivatives were prepared by this method and identified by chemical derivatization method.

Design, synthesis and SAR study of novel sulfonylureas containing an alkenyl moiety

A series of sulfonylurea compounds was designed and synthesized via introducing an alkenyl moiety into the aryl-5 position and most title compounds exhibited enhanced antifungal activities and limited herbicidal activities compared with chlorsulfuron. Then, a CoMSIA calculation for antifungal activities was carried out to establish a 3D-QSAR model in which a cross-validated q2 of 0.585 and a correlation coefficient r2 of 0.989 were obtained. The derived model revealed that hydrophobic and electrostatic fields were the two most important factors for antifungal activity. Structure optimization was performed according to the CoMSIA model and compound 9z was found to be as potent as chlorothalonil in vitro against C. cornigerum, the pathogen of the wheat sharp eyespot disease. In order to study the fungicidal mechanism, 9z was successfully docked into yeast AHAS using a flexible molecular docking method and the resulting binding pattern was similar to that of chlorimuron-ethyl, indicating that the antifungal activity of compounds 9 was probably due to the inhibition of fungal AHAS.

SYNTHETIC ANALOGUES OF XANTHOHUMOL

The present invention relates to novel synthetic analogues of xanthohumol and the use thereof.

NOVEL COMPOUNDS

Novel inhibitors of Rho-kinases are disclosed.

Certain pharmaceutical sulfamoylbenzoyl benzofurans, benzothiophenes, and indoles

Heterocyclic sulfamoyl-aryl-ketones wherein the heterocyclic component consists of a benzofuran, indole or benzothiophene radical and the sulfamoyl-aryl moiety is ortho-substituted by halogen, methyl or trifluoromethyl having uricosuric, hypouricemic and salidiuretic action and a process for their manufacture.