3-chloro-N-{(1S)-1-(4-{[2-{4-[(2S)-2-[({3-chloro-4-[(1-methylethyl)oxy]phenyl}carbonyl)amino]-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]phenyl}-8-(1-hydroxyethyl)imidazo[1,2-a]pyridin-3-yl]acetyl}phenyl)-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide

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Chemical Name:3-chloro-N-{(1S)-1-(4-{[2-{4-[(2S)-2-[({3-chloro-4-[(1-methylethyl)oxy]phenyl}carbonyl)amino]-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]phenyl}-8-(1-hydroxyethyl)imidazo[1,2-a]pyridin-3-yl]acetyl}phenyl)-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide
CAS No.:1240138-02-6
Molecular Formula:C₆₅H₅₈Cl₂N₆O₁₀
Molecular Weight:1154.12
Hs Code.:

3-chloro-N-{(1S)-1-(4-{[2-{4-[(2S)-2-[({3-chloro-4-[(1-methylethyl)oxy]phenyl}carbonyl)amino]-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]phenyl}-8-(1-hydroxyethyl)imidazo[1,2-a]pyridin-3-yl]acetyl}phenyl)-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide

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Chemical Property of 3-chloro-N-{(1S)-1-(4-{[2-{4-[(2S)-2-[({3-chloro-4-[(1-methylethyl)oxy]phenyl}carbonyl)amino]-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]phenyl}-8-(1-hydroxyethyl)imidazo[1,2-a]pyridin-3-yl]acetyl}phenyl)-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide

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Technology Process of 3-chloro-N-{(1S)-1-(4-{[2-{4-[(2S)-2-[({3-chloro-4-[(1-methylethyl)oxy]phenyl}carbonyl)amino]-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]phenyl}-8-(1-hydroxyethyl)imidazo[1,2-a]pyridin-3-yl]acetyl}phenyl)-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide

There total 12 articles about 3-chloro-N-{(1S)-1-(4-{[2-{4-[(2S)-2-[({3-chloro-4-[(1-methylethyl)oxy]phenyl}carbonyl)amino]-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]phenyl}-8-(1-hydroxyethyl)imidazo[1,2-a]pyridin-3-yl]acetyl}phenyl)-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 936718-00-2
2-amino-3-[(1S)-1-hydroxyethyl]pyridine

: 1240138-00-4
N, N'-([(2E)-1,4-dioxo-2-butene-1,4-diyl]bis{benzene-4,1-diyl[(2S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,2-propanediyl]})bis{3-chloro-4-[(1-methylethyl)oxy]benzamide}

: 1240138-02-6
3-chloro-N-{(1S)-1-(4-{[2-{4-[(2S)-2-[({3-chloro-4-[(1-methylethyl)oxy]phenyl}carbonyl)amino]-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]phenyl}-8-(1-hydroxyethyl)imidazo[1,2-a]pyridin-3-yl]acetyl}phenyl)-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide

Guidance literature:: In acetonitrile; for 74h; Reflux;
DOI:10.1021/op100186c

Reference yield:

: 3182-95-4
L-Phenylalaninol

: 1240138-02-6
3-chloro-N-{(1S)-1-(4-{[2-{4-[(2S)-2-[({3-chloro-4-[(1-methylethyl)oxy]phenyl}carbonyl)amino]-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]phenyl}-8-(1-hydroxyethyl)imidazo[1,2-a]pyridin-3-yl]acetyl}phenyl)-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethyl acetate / 1.5 h

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / methanol; toluene / 42 - 60 °C

2.2: 2 h / 60 °C

3.1: aluminum (III) chloride / 22 h / -5 °C

3.2: 35 - 50 °C

3.3: 18 h / 65 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 - 8 °C

5.1: tetrabutylammomium bromide; water; potassium formate / acetonitrile / 40 h / Reflux

6.1: copper diacetate / methanol / 2.5 h / 50 - 60 °C

7.1: triethylamine / isopropyl alcohol; acetonitrile / 5 h / 20 °C

8.1: acetonitrile / 74 h / Reflux

With aluminum (III) chloride; di-isopropyl azodicarboxylate; tetrabutylammomium bromide; water; copper diacetate; potassium formate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; ethyl acetate; isopropyl alcohol; toluene; acetonitrile; 2.1: Mitsunobu reaction / 3.1: Friedel Crafts acylation / 7.1: Wittig reaction;
DOI:10.1021/op100186c

Reference yield:

: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

: 1240138-02-6
3-chloro-N-{(1S)-1-(4-{[2-{4-[(2S)-2-[({3-chloro-4-[(1-methylethyl)oxy]phenyl}carbonyl)amino]-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]phenyl}-8-(1-hydroxyethyl)imidazo[1,2-a]pyridin-3-yl]acetyl}phenyl)-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / methanol; toluene / 42 - 60 °C

1.2: 2 h / 60 °C

2.1: aluminum (III) chloride / 22 h / -5 °C

2.2: 35 - 50 °C

2.3: 18 h / 65 °C

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 - 8 °C

4.1: tetrabutylammomium bromide; water; potassium formate / acetonitrile / 40 h / Reflux

5.1: copper diacetate / methanol / 2.5 h / 50 - 60 °C

6.1: triethylamine / isopropyl alcohol; acetonitrile / 5 h / 20 °C

7.1: acetonitrile / 74 h / Reflux

With aluminum (III) chloride; di-isopropyl azodicarboxylate; tetrabutylammomium bromide; water; copper diacetate; potassium formate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; isopropyl alcohol; toluene; acetonitrile; 1.1: Mitsunobu reaction / 2.1: Friedel Crafts acylation / 6.1: Wittig reaction;
DOI:10.1021/op100186c